The patients suffer from end-stage renal disease and must receive renal replacement therapy, including of hemodialysis, peritoneal dialysis, renal transplantation. Renal transplantation can improve survival and life quality of patients with end-stage renal disease. Survival of diabetic patients after renal transplantation is 75 ~ 80% at five years, markedly better than those seen with dialysis, where the five-year patient survival rate is 30%. The underlying reasons for improved survival with renal transplantation, compared with dialysis, are unclear. However, since a functioning renal allograft more closely resembles a normal kidney than does maintenance dialysis therapy, it is possible that the survival benefit may result in part from improved clearance of uremic toxins.