第二次腎臟移植的近況與發展

Long-Term Outcome on Second Kidney Transplantations

張登翔(Teng-Hsiang Chang) ； 張家築(Chia-Chu Chang) ； 邱炳芳(Pin-Fang Chiou)

《腎臟與透析》 30卷1期 (2018/03) Pp. 6-9

https://doi.org/10.6340/KD.201803_30(1).0002

摘要

腎臟移植是末期腎臟病病患目前已知最好的腎臟替代治療，成功的腎臟移植可以帶給病患更好的存活率跟生活品質。近年因醫學的進步所以短期存活率有大幅度的提升，但長期存活率進步仍有限，根據國外研究顯示，一個屍體捐贈的腎臟可以使用8.8年，而活體捐贈可以使用12年，所以接受腎臟移植的患者將來很有可會遇到移植腎失敗，重新登入等待換腎名單。此篇文章主要就第一次腎臟移植失敗後的處置做討論，跟研究第二次腎臟移植的預後跟危險因子。

關鍵字

腎臟移植 ； 免疫抑制劑 ； 腎臟切除手術

並列摘要

Renal transplantation is an optimal treatment for patients with end-stage renal disease (ESRD). In general, a successful primary (i.e., first) kidney transplantation (KT) provides substantially longer survival and better quality of life than dialysis with similar characteristics. Despite short-term graft survival has improved in the past decade, long-term graft survival is still limited. The average survival of a KT is 8.8 years for deceased and 12 years for living donor transplants. Therefore, we are seeing an increasing number of patients being relisted for a second KT worldwide as most KT patients will eventually face graft failure. The aim of this study was to discuss the management of the graft loss patient, and long-term outcomes of second kidney transplantations and risk factors predictive of second KT outcome.

並列關鍵字

kidney transplantation ； immunosuppressant ； nephrectomy