- 期刊
次發性副甲狀腺機能亢進的診斷及治療
Diagnosis and Treatment of Secondary Hyperparathyroidism
摘要
次發性副甲狀腺機能是慢性腎臟病患者的常見併發症之一。致病機轉和高血磷、低血鈣、活性維他命D缺乏、纖維母細胞生長因子－23上升和副甲狀腺素抗性相關。治療包括以限磷飲食和磷離子結合劑治療高血磷和低血鈣、以活性維他命D或維他命D類似物治療維他命D缺乏。病患合併有高血鈣時可考慮擬鈣劑。頑固的副甲狀腺機能亢進建議副甲狀腺切除手術。副甲狀腺介入療法的長期療效仍未有定論。
並列摘要
Secondary hyperparathyroidism is one of the most common complications among patients with advanced chronic kidney disease. The pathophysiology of secondary hyperparathyroidism is associated with hyperphosphatemia, hypocalcemia, calcitriol deficiency, elevated fibroblast growth factor-23, and parathyroid hormone resistance. Treatments of secondary hyperparathyroidism include corrections of hyperphosphatemia and hypocalcemia by restriction of high phosphate diet and the use of phosphate binder, and calcitriol or vitamin D analogue for calcitriol deficiency. Calcimimetics is considered for hyperparathyroidism with hypercalcemia. Parathyroidectomy is indicated for refractory hyperparathyroidism. The efficacy of parathyroid intervention therapy remains uncertain.
延伸閱讀
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- 潘筱芳、林軒維、林玉怡、郭錦松（2018）。甲狀腺功能亢進的診斷及治療。台北市醫師公會會刊，62(2)，26-33。https://www.airitilibrary.com/Article/Detail?DocID=P20110322001-201802-201802260006-201802260006-26-33
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