慢性腎臟病與心臟血管疾病

Cardiovascular Disease in Chronic Kidney Disease

張耘綸(Yun-Lun Chang) ； 丁羿文(I-Wen Ting)

《腎臟與透析》 30卷4期 (2018/12) Pp. 183-186

https://doi.org/10.6340/KD.201812_30(4).0004

摘要

心臟血管疾病是慢性腎臟病患的首要死因，臨床上以左心室功能不良、冠狀動脈疾病、高血壓及共同的終點，心臟衰竭，為最常見。左心室功能不良主要為慢性體液過剩與壓力過載造成的心肌肥大與功能失償。冠狀動脈疾病由傳統和非傳統危險因子如高同半胱胺酸、發炎和不正常一氧化氮系統等造成。而高血壓是最容易忽略控制的部分，除了腎素－血管張力素－醛固酮系統調控失常，也和交感神經過度興奮與不正常血管內皮系統有非常大的關聯。本文將分別探討。

關鍵字

慢性腎臟病 ； 心臟血管疾病 ； 心臟衰竭

並列摘要

Cardiovascular disease is the leading cause of death in chronic kidney disease patients. Left ventricular dysfunction, coronary artery disease, hypertension, and their common endpoint, heart failure, are the most common types. Left ventricular dysfunction is mainly caused by chronic volume overload and pressure overload, which result in cardiac hypertrophy and dysfunction. Traditional and non-traditional risk factors such as hyperhomocysteinemia, inflammation, and abnormal nitric oxide systems lead to coronary artery disease. Hypertension is the most easily overlooked problem. In addition to the abnormal regulation of the renin-angiotensin-aldosterone system, it is also highly related to sympathetic overactivity and endothelium dysfunction. This article will explore these diseases.

並列關鍵字

chronic kidney disease ； cardiovascular disease ； heart failure