- 期刊
敗血症及急性腎損傷的血液淨化治療
Nutritional Assessment and Intervention in Critically Ill Patients With Acute Kidney Injury
摘要
敗血症是住院及重症監護病房患者發生急性腎損傷（acute kidney injury, AKI）的主要原因。腎臟替代治療（renal replacement therapy, RRT）仍是敗血症相關AKI的重要治療手段之一。新型膜材及多種血液淨化技術不斷應用於敗血症的治療，但目前不論高截留、高吸附膜濾器RRT，還是血液灌流、血漿置換、配對血漿濾過吸附（couple plasma filtration adsorption, CPFA）等手段，均尚缺乏高證據等級的循證證據表明能顯著改善敗血症患者的生存率。期待後續針對新型膜材的更多臨床研究結果，以及對不同亞組患者的選擇，從而為敗血症血液淨化治療帶來更清晰的方向。
並列摘要
Sepsis is the leading cause of acute kidney injury (AKI) in hospitalized and intensive caring unit patients. Renal replacement therapy (RRT) is still the fundamental treatment for patients with sepsis-associated AKI. New types of membrane and various blood purification techniques have been applied for sepsis treatment. However, a clear positive effect on patient survival has not been proven by any of the current techniques, including RRT with high cut-off membrane or highly adsorptive membrane filter, hemoperfusion, plasma exchange, couple plasma filtration adsorption (CPFA), etc. Results from more studies related to new membrane and studies carrying out in subgroup of sepsis patients are expected to bring more clear direction for blood purification therapy on sepsis.
延伸閱讀
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