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異體移植骨在牙周病治療上的應用:文獻回顧

Allograft in Periodontal Therapy: A Literature Review

摘要


牙周病治療的目標在於恢復喪失的牙周組織,換言之希望能達到下列的要求:使探測深度降低、臨床附連獲得、填補骨缺損和具有新骨、新牙骨質、新的牙周膜的再生。目前使用移植骨扮演相當重要的角色。使用異體移植骨比對照組不使用異體移植骨可以有較多的骨填補,即使如此這些新生的骨仍然無法達到我們所期盼的牙周組織完全再生的目標。但是異體移植骨大致符合我們對於使用移植骨的要求,另外使用異體移植骨最重要最值得注意的是它的安全性及疾病傳染的可能性。本文獻的回顧將探討異體骨移植及骨銀行的歷史,異體骨移植的動物實驗及其脫鈣與否在牙周病上的應用,異體移植骨合併引導組織再生的效果並對骨誘發的能力及其影響的因子和使用異體移植骨的安全性。

並列摘要


The goal of periodontal therapy is to restore the lost periodontal apparatus. In other words, we hope to achieve the followings: decrease of probing depth、gain of clinical attachment level, bone fill and regeneration of new bone, new cementum and periodontal ligament. Currently, the use of bone graft material plays an important role in this regards. Allograft, especially decalcified freeze-dried bone allograft (DFDBA) did show better results compared to non-graft treatment from the literature. Even though, the DFDBA could meet the requirements for the bone graft. The bone inductive ability of DFDBA could be affected due to different methods of processing, sources of donors, and different amount of bone morphogenetic protein. Because of allograft is from foreign body, the safety and disease transmission should be paid more attention. This paper will review and focus on the history of allograft bank, animal studies and human studies on allograft in periodontal therapy, the bone inductive ability, and safety.

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