鎝-99m MIBI肝癌造影：與P-醣蛋白-多藥物抗藥性基因表現的相關性

Tc-99m MIBI Liver Imaging for Hepatocellular Carcinoma: Correlation with P-Glycoprotein multidrug-resistance Gene Expression

林君宜(Chun-Yi Lin) ； 莊豐如(Feng-Ju Chuang) ； 孫盛生(Shung-Shung Sun)

《Mid-Taiwan Journal of Medicine》 8卷s_1期 (2003/11) Pp. s1-s7

https://doi.org/10.6558/MTJM.2003.8(s_1).1

摘要

目的 鎝-99m MIBI造影在確定若干種類的腫瘤時已經顯示有用，例如乳癌、肺癌和甲狀腺癌。鎝-99m MIBI的造影對於肝癌的研究在文獻只有一些報告且結果並不一致。這個研究的目的是要探討鎝-99m MIBI肝癌造影與P-醣蛋白-多藥物抗藥性基因表現的相關性。
方法 二十二個肝癌患者被納入這個研究。病人在靜脈注射20mCi鎝-99m MIBI後10分鐘再進行鎝-99m MIBI肝癌造影。所有病人在進行鎝-99m MIBI肝癌造影的一星期之內都做過肝臟活組織切片檢查或手術。利用抗-人類P-醣蛋白的抗體來進行肝臟活組織切片和切除的肝癌標本的免疫組織染色。
結果 二十二個肝癌患者中，有20個肝癌患者（90.9%）在腫瘤病灶中呈現陰性的鎝-99m MIBI肝癌造影，而僅有2個病人在腫瘤病灶中呈現陽性的鎝-99m MIBI肝癌造影。在20個腫瘤病灶中呈現陰性鎝-99m MIBI肝癌造影的肝癌患者中有13病人（65%）P-醣蛋白呈現陰性反應。而在腫瘤病灶中呈現鎝-99m MIBI肝癌造影的2個病人中，P-醣蛋白的表現都呈現陰性。
結論 鎝-99m MIBI肝癌造影在預測肝癌病人中P-醣蛋白-多藥物抗藥性基因的表現上是一個有用且非侵入性的檢查方法。

關鍵字

肝癌 ； P-醣蛋白-多藥物抗藥性基因 ； 鎝-99m MIBI

並列摘要

Objectives. Tc-99m MIBI is a useful method for identifying breast, lung and thyroid cancers. However, only a few reports have focused on the uptake of Tc-99m MIBI in hepatocellular carcinoma. The aim of this study was to investigate the relationship between Tc-99m MIBI accumulation in HCC and the expression of p-glycoprotein-mdr.
Methods. We selected 22 patients with hepatocellular carcinoma. Tc-99m MIBI SPECT was performed 10 minutes after intravenous injection of 20mGI Tc-99m MIBI. All patients underwent either liver biopsy or surgery with in 1 week of MIBI imaging. Immunohistochemical study of the biopsy specimens and the resected hepatocellular carcinoma specimens was performed with anti-human p-glycoprotein antibody.
Results. There was no uptake of Tc-99m MIBI by tumor lesions in 20 out of the 22 (90.9%) patients. p-Glycoprotein expression was observed in 13 out of 20 (65%) patients with no Tc-99m MIBI uptake. There was no expression in the 2 patients with positive Tc-99m MIBI uptake.
Conclusions. Tc-99m MIBI SPECT is a useful non-invasive method for predicting the expression of the p-glycoprotein multidrug-resistance gene in hepatocellular carcinoma patients.

並列關鍵字

hepatocellular carcinoma ； p-glycoprotein multidrug-resistance gene ； Tc-99m MIBI