A 58-years-old postmenopausal woman with history of Thalassemia, who also had received operation and chemotherapy because of right breast tumor. She complained urgency and frequency of micturition for one year. She was diagnosed as overactive bladder and was given prescription with anti-muscarinics by an urologist for one year. However, her symptoms became worse and severely affected the quality of her life, so she came to Chinese medicine for help. After a two-months-treatment of Chinese herbal medicine and acupuncture, the symptoms of frequent and urgent urination improved a lot, promoted the quality of life obviously.