Dyspnea is one of the most common symptoms in palliative care patients. To manage patients with the will of "do not intubate", respiratory therapists should be familiar with the assessments and strategies of dyspnea, in addition to the use of a non-invasive ventilator. Strategies to treat dyspnea include sedatives, analgesics, aerosolized drugs, breathing retraining, pulmonary rehabilitation, as well as non-traditional remedies, such as relaxation techniques, neuromuscular stimulations, and acupuncture. The anxiety of those patients and their families hopefully can be reduced, and the patients' quality of life can be improved.