Clinical Presentations Associated with Anti-Jo-1 Antibody in Patients with Polymyositis and Dermatomyositis

多發性肌炎和皮肌炎病患臨床表現與抗Jo-1抗體之相關性

方耀凡(Yao-Fan Fang) ； 羅淑芬(Shue-Fen Luo) ； 郭昶甫(Chang-Fu Kuo) ； 何輝煌(Huei-Huang Ho) ； 劉烈邦(Lieh-Bang Liou) ； 陳基益(Ji-Yih Chen) ； 余光輝(Kuang-Hui Yu)

《Formosan Journal of Rheumatology》 26卷1&2期 (2012/12) Pp. 15-22

https://doi.org/10.6313/FJR.2012.26(1-2).03

摘要

Background: Polymyositis and dermatomyositis are idiopathic inflammatory myopathies and anti-Jo-1 is the most common autoantibody found in inflammatory myositis patients. We aimed to demonstrate clinical symptoms and signs related to anti-Jo-1 antibody in patients with polymoyositis and dermatomyositis.Materials and Methods: We retrospectively reviewed medical records of 151 patients with polymoyositis and dermatomyositis in Chang Gung Memorial Hospital from 2000 to 2007.Results: Eighty (53%) of 151 patients had identified anti-Jo-1 antibody. Interstitial lung disease, cardiac involvement, hypertension, and dysphagia were associated with the presence of anti-Jo-1 antibody according to univariate analysis (p=0.011, ＜0.001, 0.045, and 0.005, respectively). Multivariate analysis, after adjusting for gender, showed that only interstitial lung disease (odds ratio = 7.49, 95% CI = 1.12-49.91, p=0.037) and cardiac involvement (odds ratio = 9.39, 95% CI = 1.34-165.83, p=0.024) were associated with the presence of anti-Jo-1 antibody. Kaplan-Meier survival analysis was not significantly lower in anti-Jo-1 positive patients than that in those without anti-Jo-1 antibody (p=0.201).Conclusion: This study highlights the clinical symptoms and signs related to anti-Jo-1 antibody in polymoyositis and dermatomyositis. Clinical presentation of interstitial lung disease and cardiac involvement were significantly associated with the presence of anti-Jo-1 antibody although anti-Jo-1 antibody had no influence on survival.

關鍵字

抗Jo-1抗體 ； 多發性肌炎 ； 皮肌炎

並列摘要

Background: Polymyositis and dermatomyositis are idiopathic inflammatory myopathies and anti-Jo-1 is the most common autoantibody found in inflammatory myositis patients. We aimed to demonstrate clinical symptoms and signs related to anti-Jo-1 antibody in patients with polymoyositis and dermatomyositis.Materials and Methods: We retrospectively reviewed medical records of 151 patients with polymoyositis and dermatomyositis in Chang Gung Memorial Hospital from 2000 to 2007.Results: Eighty (53%) of 151 patients had identified anti-Jo-1 antibody. Interstitial lung disease, cardiac involvement, hypertension, and dysphagia were associated with the presence of anti-Jo-1 antibody according to univariate analysis (p=0.011, ＜0.001, 0.045, and 0.005, respectively). Multivariate analysis, after adjusting for gender, showed that only interstitial lung disease (odds ratio = 7.49, 95% CI = 1.12-49.91, p=0.037) and cardiac involvement (odds ratio = 9.39, 95% CI = 1.34-165.83, p=0.024) were associated with the presence of anti-Jo-1 antibody. Kaplan-Meier survival analysis was not significantly lower in anti-Jo-1 positive patients than that in those without anti-Jo-1 antibody (p=0.201).Conclusion: This study highlights the clinical symptoms and signs related to anti-Jo-1 antibody in polymoyositis and dermatomyositis. Clinical presentation of interstitial lung disease and cardiac involvement were significantly associated with the presence of anti-Jo-1 antibody although anti-Jo-1 antibody had no influence on survival.

並列關鍵字

Anti-Jo-1 ； polymyositis ； dermatomyositis