Cold rolling coil annealing processes is a very widely used technology in the automobile body industry, yet the characteristics of its product are easily affected by the processing conditions such as ratio of rolling, first stage isothermal temperature, second stage isothermal temperature, time of first stage isothermal temperature, time of second stage isothermal temperature. In this paper, an effective methodology for cold rolling coil annealing processes optimization is proposed. The method includes validity and reliability analysis of data, orthogonal array of experimental design of Taguchi, analysis of variance (ANOVA), neural-based manufacturing process optimization, Genetic Algorithm and grey relational analysis.By using these methods, we can find the optimal annealing process easier and faster than the traditional method that try and error in higher strength, higher stiffness, and faster productivity and safety materials to meet the demands upon structure design and economic benefit.