Deep neck infection is nor uncommon. Its mortality rate is relatively high. The mortality rate may be up to 40% when it is complicated by mediastinal empyema and sepsis. The disease is a challenge to both the otolaryngologist and thoracic surgeon. This report presents a case of retropharyngeal abscess complicated by mediastinal and pleural empyema. We consulted a thoracic surgeon to insert chest tubes for immediate drainage. Debridement and drainage of the cervical abscess and endotracheal intubation to maintain a patent airway were also performed. The pus culture revealed both Hemolytic Strepto-coccus and Staphylococcus aureus. Antibiotic therapy with clindamycin and gentamycin was given. The chest tubes were removed after the empyema resolved. The patient was discharged in stable condition on the 37th day after admission. Correct diagnosis and early treatment of deep neck infection are the best ways to prevent mediastinal and pleu-ral complications.