The Effectiveness of Indomethacin Skin PAP for Acute Renal Colic

引朵美洒辛皮膚貼布治療急性腎絞痛之評估

林明正(Min-Zen Lin) ； 于大雄(Dah-Shyong Yu) ； 馬正平(Cheng-Ping Ma) ； 楊泰和(Tai-Hou Yang)

《中華民國泌尿科醫學會雜誌》 6卷1期 (1995/03) Pp. 13-17

https://doi.org/10.7024/JUAROC.199503.0013

摘要

腎絞痛通常劇痛且合併噁心嘔吐。一種有效、低副作用的藥劑，可以馬上緩解疼痛是必需的。從一九九四年四月至七月，我們於急診室共收集了八十位腎絞痛病患。分成四組，以下述四種不同方式治：第一組十九位病患以靜脈輸液治療：第二組十二位病患以靜脈輸液及口服引朵美酒辛及 buscopon 治療；第三組二十三位病患以靜脈輸液及肌肉注射 merperidine及atropine治療；第四組二十六位病患以靜脈輸液加上引朵美酒辛皮膚貼布治療。腎絞痛程度分級由第一級的無痛至第六級的不可忍受的疼痛。問卷記錄治療前後之疼痛分數及噁心嘔吐頻率並無特別差異。目前引朵美酒辛皮膚貼布藥劑使用方法尚不足以緩解腎絞痛。進一步研究調整藥布成份、劑量及使用時間，可能有助於將來對腎絞痛之控制。

關鍵字

急性腎絞痛 ； 引朵美酒辛 ； 皮膚貼布

並列摘要

Renal colic is usually painful and associated with nausea or vomiting. From April to July 1994, 80 patients with acute renal colic were enrolled in this study on arriving our emergency room. They were divided into four groups randomly and treated with different protocols. Group 1 of 19 cases were treated with intravenous normal saline alone, group 2 of 12 cases were treated with intravenous normal saline plus oral administration of indomethacin and buscopan, group 3 of 23 cases were treated with intravenous normal saline plus intramuscular injection of merperidine and atropine, and group 4 of 26 cases were treated with intravenous normal saline and indomethacin skin PAP. The severity of pain was classified into six grades from pain-free grade 1 to grade 6 with intolerable pain. Questionnaire was taken on pain score and frequency of nausea and/or vomiting before and after treatment. The result showed no significant difference in pain relief and frequency of nausea and/or vomiting among each group. In conclusion, current indomethacin skin RAP formula and application is not truly effecitive in relieving acute renal colic. Futher study with modification of the component of skin PAP or increased dosage and application time should be conducted.

並列關鍵字

acute renal colic ； indomethacin ； skin PAP