摘要
台大醫院耳鼻喉科於1990年1月至同年12月間，由鼻過敏特別門診中，篩選20名過敏性鼻炎的患者，進行免疫療法（immunotherapy）。由臨床症狀、局部所現及皮膚試驗的結果，他們主要都是對家塵抗原過敏者。治療前，每名病人皆抽血，分別以PRIST及FAST測IgE總量、抗蟎 特定性IgE及IgG4，並作鼻部粘膜刮搔檢查。病人每週接受1次皮下過敏原注射，每3個月測1次抗體。追蹤期限由9個月至1年不等。結果顯示，疫療法對打噴嚏的改善率（response rate）為89.4％，IgG4隨著治療時間的增加，有逐漸增加的趨勢（p＜0.01），特定性IgE則治療前後無顯著差異，IgE總量，整體就統計上而言，呈現逐漸減少的趨勢（p＜0.05），而鼻粘膜上的嗜紅性白血球及嗜鹼性白血球，則無法做診斷的依據及治療效果的指標。若慎選符疫療法條件的病人，疫療法是一有效的治療方法。
並列摘要
Twenty cases of allergic rhinitis were treated with immunotherapy from January to December 1990. Twelve cases were treated for 9 months and the others for 12 months. The nasal scrapings were performed every month. The serum total IgE, specific IgE and IgG4 were checked every 3 months. The results were analysed with repetitive measures. The IgG4 was increasing during immunotherapy (p＜0.01), while the total IgE was decreasing. (p＜0.01). The specific IgE didn’t show significant changes (p＞0.05). The eosinophil and basophilic cells of the nasal mucosa couldn’t be taken as diagnostic criteria, or as indicator of whether the treatments were effective or not. The response rate of sneezing was 89.4%. Therefore, we may well conclude that immunotherapy is effective in allergic rhinitis if patients be selected adequately.
延伸閱讀
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