Chondrosarcoma originating in the cose and paranasal sinuses is very rare. It is often found to be greatly advanced by the time a clinical or radiologic diagnosis is established. Therefore, the overall cure rated is low, even when surgery and readiation therapy are combined. A case of chondrosarcoma fo left sphenoid sinus with parasellar invasion which presented with a progressive cranial neuropathies and nasal mass is reported. In this patient, the major symptoms and signs were nasal obstruction, bloody nasal discharge, nasal mass, and multiple cranial nerve palsies. Usully, the chondrosarcoma presents as a large, whitish to blueish-gray mass, low in grade, whitish to blueish-gray mass, low in grade, insidious but locally invasive to adjacent tissue. Computed tomography may reveal a soft tissue mass expanding and destroying bone and typically showing areas of nodular or plaque-like calcification. The treatment of choice for chondrosarcomas of paranasal sinus is by en block excision. Adjuvant radiotherapy may be considered, particularly in non-resectable or recurrent tumors. The prognosis is usually poor eventually.