This paper is trying to discuss market orientation; the relationship between departments and organization interactions; the compatibility of organization culture and how environment uncertainty affects the interaction between departments and organizations. This research was based on the results of question surveys. There were 167 companies completed the questionnaires out of 791 that were sent out to TOP 1000 manufacturers ranked in the CWbook magazine. The results are as follows: 1. The interaction process within departments would be affected by how companies consider their market orientation. 2. More effective departments interactions; more influence in the organizations' interactions. 3. The compatibility of companies' culture have the power to disturb the interactions between organizations and departments. 4. The uncertainty of environment has no effect on the interactions between organizations and departments.