To investigate the diagnostic values in detecting experimental pancreatic cancer, serum levels of amylase, ribonuclease, and carbohydrate antigen 19-9 were assayed in 59 hamsters treating with intraperitoneal injection of N-nitrosobis (2-oxopropyl) amine (B. O. P.) and 51 healthy controls. Totally 22 (37.3%) out of 59 hamsters after B. O. P. treatment developed pancreatic cancer within 22 weeks, while none of the 51 controls developed any tumor, in the same period. Serum amylase levels remained unchanged till the 18th week when the B. O. P. -treated group had higher levels as compared to those of control group (P<0.01), and the difference persisted up to the 20th (P<0.001) and 22nd week (P<0.005). It seemed valuable to detect the experimental pancreatic cancer at its earlier stage by determination of serum amylase. The serum ribonuclease levels raised transiently at the 18th and 20th weeks in the B. O. P.-treated group (P<0.05), but the difference was unremarkable at the 22nd week. Thus, measurement of serum ribonuclease is of limited value in the diagnosis of this experimental cancer. Serum carbohydrate antigen 19-9 was always below 6U/ml in all animals and was useless in the hamster system. We conclude that only serum amylase determination might have potential value in the diagnosis of experimental pancreatic cancer at its earlier stage.
To investigate the diagnostic values in detecting experimental pancreatic cancer, serum levels of amylase, ribonuclease, and carbohydrate antigen 19-9 were assayed in 59 hamsters treating with intraperitoneal injection of N-nitrosobis (2-oxopropyl) amine (B. O. P.) and 51 healthy controls. Totally 22 (37.3%) out of 59 hamsters after B. O. P. treatment developed pancreatic cancer within 22 weeks, while none of the 51 controls developed any tumor, in the same period. Serum amylase levels remained unchanged till the 18th week when the B. O. P. -treated group had higher levels as compared to those of control group (P<0.01), and the difference persisted up to the 20th (P<0.001) and 22nd week (P<0.005). It seemed valuable to detect the experimental pancreatic cancer at its earlier stage by determination of serum amylase. The serum ribonuclease levels raised transiently at the 18th and 20th weeks in the B. O. P.-treated group (P<0.05), but the difference was unremarkable at the 22nd week. Thus, measurement of serum ribonuclease is of limited value in the diagnosis of this experimental cancer. Serum carbohydrate antigen 19-9 was always below 6U/ml in all animals and was useless in the hamster system. We conclude that only serum amylase determination might have potential value in the diagnosis of experimental pancreatic cancer at its earlier stage.