A Comparison of Immunogenicity of Reduced Doses of Hepatitis B Vaccine in Infants Born to Noncarrier Mothers in Taiwan

臺灣非帶原母親之新生兒對不同低劑量B型肝炎疫苗免疫反應之比較研究

蔡養德(Yang-Te Tsai) ； 羅光瑞(Kwang-Juei Lo) ； 李壽東(Shou-Dong Lee) ； 王覲瑜(Jiin-Yu Wang) ； 吳肇卿(Jaw-Ching Wu) ； 陳祖裕(Chou-Yu Chang) ； 吳子聰(Tzee-Chung Wu)

《中華民國消化系醫學會雜誌》 4卷2期 (1987/06) Pp. 56-62

https://doi.org/10.6557/GJTa.198706_4(2).0002

摘要

To compare the immunogenic effect of a reduced dose of hepatitis B vaccine in infants born to noncarrier mothers, we randomly divided 298 infants into 3 groups to receive 3 different doses of 5 μg (group A: 101 infants), 2μg (group B: 99 infants) and l μg (group C: 98 infants) of Pasteur plasma vaccine. The immunization protocol involved 3 injections of vaccine starting within one week after birth at one month intervals, and a booster at one year. At six months, infants of group A had significant increased rate of anti-HBs response rate (96%) when they compared with group B (85%) and group C (76%). Seven percent of vaccinees lost their antibody before booster, but it rose rapidly to 97, 92, and 88% respectively in group A, B and C at 2 months after booster injection. The geometric mean titers of anti-HBs was significantly higher in group A responders as compared to group B and C at ages of 6, 12, and 14 months. This study shows that standard 4 doses 5 µg Pasteur hepatitis B vaccine is most appropriate for mass immunization of infants born to noncarrier mothers in Taiwan. No adverse reactions were observed.

關鍵字

肝炎疫苗

並列摘要

To compare the immunogenic effect of a reduced dose of hepatitis B vaccine in infants born to noncarrier mothers, we randomly divided 298 infants into 3 groups to receive 3 different doses of 5 μg (group A: 101 infants), 2μg (group B: 99 infants) and l μg (group C: 98 infants) of Pasteur plasma vaccine. The immunization protocol involved 3 injections of vaccine starting within one week after birth at one month intervals, and a booster at one year. At six months, infants of group A had significant increased rate of anti-HBs response rate (96%) when they compared with group B (85%) and group C (76%). Seven percent of vaccinees lost their antibody before booster, but it rose rapidly to 97, 92, and 88% respectively in group A, B and C at 2 months after booster injection. The geometric mean titers of anti-HBs was significantly higher in group A responders as compared to group B and C at ages of 6, 12, and 14 months. This study shows that standard 4 doses 5 µg Pasteur hepatitis B vaccine is most appropriate for mass immunization of infants born to noncarrier mothers in Taiwan. No adverse reactions were observed.

並列關鍵字

hepatitis B vaccine