- 期刊
Detrimental Effects of Cadmium on the Rat Liver after Partial Hepatectomy or Carbon Tetrachloride Induced Hepatic Injury
鎘對大白鼠肝臓部份切除或四氯化碳損害後之影響
摘要
台灣地區慢性B型肝炎病患眾多，部份會惡化成肝硬化或肝癌。鎘對肝臟是有損害的，而本地區食物如稻米受工業鎘污染事件常有所聞，二者之間是否有所關聯，是值得進一步探討的。 為了評估鎘對受損害之肝臟影響，吾等選擇了303只雄性大白鼠作三分之二之部份肝切除術或注射四氯化碳造成肝損害之動物實驗。本實驗共分七組：(1)44只鼠接受假手術及食鹽水(1ml/kg)之注射，(2)44只鼠接受三分之二肝切除術後再接受食鹽水注射，(3)23只鼠接受三分之二肝切除術後再行注射硫化鎘(2ml/kg), (4)48只鼠僅接受食鹽水之注射，(5)48只鼠僅接受硫化鎘之注射，(6)48只鼠先經注射四氯化碳(6670ml/kg)造成肝損害後，再注射食鹽水，(7)48只鼠經注射四氯化碳後，再注射硫化鎘，最後定期(1, 2, 5, 7天)犧牲大白鼠數只，以測定其血液中AST, ALT和β-glucuronidase值。 結果在接受部份肝切除術之鼠組中，接受食鹽水注射者，沒有死亡產生，而23只白鼠接受硫化鎘注射，有20只在24小時內死亡，存活的3只則有較高的肝轉氨酶值。在復有接受手術之鼠組中，單獨注射硫化鎘的鼠明顯的比注射食鹽水的鼠有較高的肝轉氨酶。而經四氯化碳損害後之鼠肝，如再接受硫化鎘注射，則會產生更高之肝轉氨酶值。由此可見，鎘不但會損害肝臟，而且對已受損之肝臟更具有破壞力。 因此吾等必須勸阻慢性肝疾患者避免服食鎘污染之食物。至於鎘污染之食物在慢性B型肝炎病患有臨床急性發作時所扮演之角色，仍待進一步求證與澄清。
並列摘要
A total of 303 male rats were used to investigate the effects of cadmium sulfate on the residual liver with minimumfunctional reserve after two-thirds hepatectomy or after carbon tetrachloride (CCl4) induced hepatic injury. In the hepatectomized group, no rat died after saline injection during the study. However, 20 of 23 rats in the cadmium sulfate treated group died within 24 hours after two-thirds hepatectomy. The survival rats in the cadmium treated group had higher levels of serum aminotransferase at 24 hours after partial hepatectomy. Cadmium administration alone significantly increased serum aminotransferase levels when compared with rats receiving saline alone. Rats which received cadmium after CCl4 administration had much higher serum aminotransferase levels than CCl4 treated rats which had not received cadmium injection. Thus, our data indicate that cadmium use if not only induces hepatic damage but also exerts a more detrimental effect on a residual liver with decreasing functional reserve after extensive hepatic resection or hepatocyte necrosis.
延伸閱讀
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