This paper employs a compressive split-Hopkinson bar to investigate the impact deformation behavior of Al-Sc alloy at different strain rate and different temperatures. The results indicate that the flow stress, work hardening rate, strain rate sensitivity and activation volume of Al-Sc alloy are all dependent on the strain, strain rate and testing temperature. It is found that the impact deformation behaviour of Al-Sc alloy can be accurately described using the Zerilli-Armstrong constitutive equation.