In this study, Taguchi empirical design and Moldex-3D are used to analyze a novel hybrid runner design for injection molds to investigate its effect on the warpage of the product. The polymer material used was optical grade PMMA. In the Taguchi L9 experimental design, the four controlling factors used are placement position, shape of structure, length of structure and gate style. The result of experiment revealed that the optimum combination of parameters was a placement at the sides, a cylindrical shape, an aligned length and a progressively reduced gate area. The error of warpage value for Taguchi confirmation experiment was 2.03% compared with the simulation value. Meanwhile, compared with the original design, the improvement in lens warpage can be as high as 22.5%. Therefore, placing special hybrid structure in the runner will effectively improve the warpage of the injection product.