中草藥萃取物與化妝品常用果酸類化合物之抗菌交互作用研究

Study on the Antibacterial Interaction of Herbal Extracts and Commonly Used Acid-based Compounds in Cosmetics

楊麗微(Li-Wei Yang) ； 翁清松(Ching-Sung Weng) ； 陳佑汲(Yu-Chi Chen)

《先進工程學刊》 12卷2期 (2017/04) Pp. 53-60

摘要

化妝品中合成抗菌劑（如Methyl Paraben(M.P.)、Propyl Paraben(P.P.)）的過度使用，經常造成皮膚過敏。因此，尋找替代以及減少合成抗菌劑成為化妝品業界的重大課題。本研究以抑制大腸桿菌為指標，檢討中草藥廣藿香萃取物與化妝品中常使用的杏仁酸及合成抗菌劑之間的體外交互（協同、加成、拮抗）作用。實驗結果顯示，中草藥廣藿香分別與杏仁酸、M.P.及P.P.一起結合使用時，對於抗大腸桿菌的能力均具有良好的協同或加成作用。這意味著，化妝品中合成抗菌劑M.P.和P.P.的配方用量可加以減少，增加以天然成分的廣藿香和杏仁酸用量進行取代，而仍能維持化妝品的整體抗菌能力。

關鍵字

合成抗菌劑 ； 大腸桿菌 ； 廣藿香 ； 杏仁酸 ； 交互作用

並列摘要

Artificial antibacterial agents (such as Methyl Paraben(M.P.) and Propyl Paraben(P.P.)) were key factors in causing skin allergies. Therefore, searching for alternatives and decreases of the artificial antibacterial agents have become a major issue in cosmetics industry. This study evaluates the in-vitro interactions (synergism, addition effect, antagonism ) between methanol extracts of Pogostemon cablin, Almond acid and two kinds of common ingredients used in cosmetics, against Escherichia coli. The results of this study showed that Pogostemon cablin possessed good synergism or addition effects when it was combined respectively with Almond acid, M.P. and P.P.. This means that the formula amounts of M.P. and P.P. can be reduced and substituted by the increased using of Pogostemon cablin extracts and Almond acid in cosmetics, and the overall antibacterial ability of cosmetics could still be able to maintain.

並列關鍵字

artificial antibacterial agents ； Escherichia coli ； Pogostemon cablin ； Almond acid ； interaction