The Squamous Cell Carcinoma with Basaloid Neuroendocrine Differentiation in Oral Cavity-A Rare Case Report

口腔內鱗狀上皮細胞癌合併基底神經內分泌細胞分化－罕見病例報告

陳建晟(Chien-Cheng Chen) ； 林鈞盛(Jiun-Sheng Lin) ； 鄭介原(Chieh-Yuan Cheng) ； 劉崇基(Chung-Ji Liu)

《臺灣口腔顎面外科學會雜誌》 25卷4期 (2014/12) Pp. 250-258

摘要

根據2005年國際衛生組織頭頸部腫瘤分類，鱗狀上皮細胞為有許多次分類，而神經內分泌細胞分化具侵犯性及臨床較差的結果。本案31歲男性診斷為左臉頰腫瘤合併同側頸部淋巴且重大，於2012年8月進行廣泛性切除、同側頸部淋巴廓清術及游離皮辮重建。組織學上經免疫細胞染色後呈現鱗狀上皮細胞為合併基底神經內分泌細胞分化，人類乳突細胞病毒感染為陰性反應。病患於術後六個月因局部及遠端擴散去世。由於口腔中罕見病例及無治療原則可循，故提出並需進一步研究及追蹤觀察。

關鍵字

頭頸部癌 ； 鱗狀上皮細胞癌 ； 神經內分泌腫瘤

並列摘要

According to the various subtypes of squamous cell carcinoma in the 2005 World Health Organization's Classification of Head and Neck Tumors, neuroendocrine differentiation has the most aggressive clinical behavior and least favorable prognosis. Our case involves a 31-year-old Taiwanese male suffering from left buccal neoplasm with ipsilateral enlarged lymph node. After performing a wide excision with modified radical neck dissection on August, 2012, the histological examination of the specimens exhibited squamous cell carcinoma with basaloid neuroendocrine differentiation and neck lymph node metastasis. The neuroendocrine differentiation was confirmed with immunohistochemical stains. The patient expired from uncontrolled recurrences and metastasis in the bone, lung and neck lymph nodes six months after the major surgery. Due to a lack of case reports in oral cavity and oropharyngeal region and no standard sequential treatment guidelines, further investigation of possible treatment options and poor prognosis should be reminded.

並列關鍵字

head and neck cancer ； squamous cell carcinoma ； Neuroendocrine carcinoma ； oral cavity