Radiation-induced Sarcomas and Sacomatoid Tumors in the Oral Cavity-Report of Two Cases

Nowadays, radiation therapy (RT) is generally used for treatment of head and neck cancers. Although it does improve the patients' survival, the post-radiation sarcomas and sarcomatoid tumors may occur but are not commonly seen. The radiation-induced tumors highly aggressive and show a rapid growth without lymph node metastasis. Surgical resection with clear margins is found to be an effective treatment. However, the 5-year survival rate of the patients is still very low. We presented two cases of radiation-induced tumors. One occurred in a 75-year-old man who had a history of oral squamous cell carcinoma (OSCC). A radiation-induced osteosarcoma was discovered at the right maxillary gingiva 40 months after adjuvant concurrent chemoradiotherapy was completed. Due to tumor recurrence, he eventually expired a half year after tumor resection. Another case occurred in a 54-year-old male patient who also had a history of OSCC. A radiation-induced sarcomatoid tumor appeared at the left lower lip vestibule extending to the left buccal mucosa 11 months after RT. After tumor resection was performed, the patient still survived.

關鍵字

Radiation-induced ； Sarcoma ； Sarcomatoid tumor ； Head and neck cancer

並列摘要

現今放射線治療已廣泛應用於頭頸癌，雖然放射線治療確實提升了存活狀況，仍會發現放射線治療誘發之肉瘤與肉瘤樣癌，這些併發症相對罕見。此類惡性腫瘤具有高侵犯性、快速生長、較少的淋巴結轉移特性，手術切除至乾淨組織邊緣是較有效的治療方式，但五年的存活率仍舊相當低。我們報告兩例關於放射線治療誘發之腫瘤病例，一為75歲男性有口腔鱗狀上皮細胞癌病史，在輔助性同步放射化學治療完成40個月後，於右上顎出現放射線治療誘發之骨肉瘤，在手術切除後半年仍復發，最終病人死亡。另一病例為54歲男性有口腔鱗狀上皮細胞癌病史，在放射線治療完成後11個月，於左側下唇前庭至左頰黏膜出現放射線治療誘發之肉瘤樣癌，經手術切除後病人現仍存活。

並列關鍵字

放射線治療誘發；肉瘤；肉瘤樣癌；頭頸癌

主題瀏覽