This study investigated the factors affecting hand grip strength of young people. The factors considered were wrist orientation, elbow angle, arm position, grip axis, the hand used, and gender. Three experiments were performed. College students between 18 and 22 years old, with no prior wrist injury and good to excellent overall physical condition were subjects. The results showed that wrist orientation, elbow angle, grip axis, the hand used, and gender had significant effects upon maximum grip strength. The effect of arm position was not significant. The best wrist orientation was the neutral, followed by ulnar deviation, radial deviation, dorsiflexion, and palmar flexion. The best elbow flexion angle is zero degree. The optimal grip axis was about 55±5 mm. The maximum grip strength of the right hand is greater than the left hand, and the maximum grip strength of male was greater than female.