The purpose of this study is to analyze the problems of hand occupational injury that caused by manual meat processing tasks in Taiwan, and to design a more ergonomic and reliable gloves for meat trimming and bone picking tasks, therefore, the operator can protect their upper limbs from injury .The contents of this study includes factory investigation, glove design principles review, experiment of grip force, and factory investigation for the new design gloves. The study result shows that the new design glove has been proved to be more effective and better in increasing the flexibility, dexterity, comfort, and stability to work with meat processing knife than the conventional gloves. This new design is also verified with the advantages such as the grip force performance better than the thick and heavy glove combination form I, while no significant difference with the glove combination form II which is similar thickness and weight.