Progressive hemi-facial atrophy or Parry-Romberg syndrome is an uncommon craniofacial disorder that typically involves the subcutaneous layer of one side of the face. Restoring the facial contour and symmetry in patients with hemi-facial atrophy remains a clinical challenge. We report on the case of a 56-year-old woman with a 10-year history of hemi-facial atrophy whose face was reconstructed using autologous fat graft by tumescent liposuction. The fat tissue was implanted into the subcutaneous area of the left side of the face, which had the defect. No complications (e.g., infection, hematoma, or a subcutaneous mass) occurred. The patient was followed up for 2 years, and the satisfactory result was lasting.