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Surgery-Related Soft Tissue Infection Caused by Non-Tuberculous Mycobacteria-Two Case Reports and A Literature Review

非結核性分枝桿菌相關的手術後軟組織感染-二則病例報告與文獻回顧

摘要


背景:非結核性分枝桿菌相關的手術後傷口感染是相當罕見的手術併發症,但是治療往往需要多次的清創手術及長時間的抗生素療法。目的及目標:整合我們的臨床經驗與文獻綜述,提出術後非結核性分枝桿菌感染的治療策略。材料及方法:我們提出兩位健康年輕女性病例,分別被診斷為非結核性分枝桿菌造成的手術後慢性軟組織感染。結果:這兩位病例皆接受清創手術合併六個月的抗生素治療後成功治癒,且追蹤結果並無復發。結論:非結核性分枝桿菌造成手術傷口感染並不常見。目前仍無實證基礎的治療程序或是標準抗生素療法的指導方針。合併手術清創及抗生素治療是建議的治療方法。我們回顧相關的文獻並結合臨床經驗提出適當的系統性臨床診斷及治療方法。

關鍵字

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並列摘要


Background: Non-tuberculous mycobacteria (NTM) infection is a rare postoperative wound complication that may need repeated surgical debridement and long-term antibiotic therapy. Aim and Objectives: Integrate our clinical experience with literature review to propose a treatment strategy of post operation NTM infection Materials and Methods: We present two cases of young and healthy women who developed postoperative chronic soft tissue infection caused by NTM.Results: The patients were successfully treated with a combination of surgical debridement and antibiotic therapy for 6 months, without reports of infection recurrence during this period. Conclusion: Surgical wound infection caused by NTM is uncommon. There is no evidence based guideline, well-established treatment protocol, or standard antibiotic regimen for their treatment. A combination of surgical debridement and long-term antibiotics treatment has been suggested. We reviewed related literature to determine a reasonable clinical approach and treatment algorithm.

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