In Taiwan, the number of individuals aged ≥65 years has increased rapidly, triggering a corresponding rise in the number of elderly people hospitalized. For elderly patients, an acute illness that requires hospitalization often causes rapid functional decline or even disability, which subsequently exacerbates family and societal burden and results in poor quality of life for affected individuals. In the article, we report the case of a 91-year-old woman hospitalized for generalized pustular psoriasis. As she underwent functional decline during hospitalization, she was moved to a nursing home after discharge. She started to experience depression at the nursing home as there was no functional improvement. Through comprehensive geriatric assessment, our transdisciplinary team studied and managed her problems through rehabilitation using an appropriate assistive device and provision of emotional support in response to her depression. Thereafter, the patient's function and quality of life gradually improved.