This work analyzed the parameters about the microbubble drag reduction by using the Taguchi method to acquire the optimal robust parametric design. Five parameters were investigated in this paper. Among these parameters, the area of air injection, the porosity of medium and the amount of air injected were regarded in the controllable factors; whereas, the flow speed and the measuring location for shear stress were classified into the indicative factors. Analyses revealed that large air supply and small area of air injection are the best for drag reduction, and the effect of medium porosity is slight. The confirmation experiments were carried out under the condition of the optimum parametric design, and the average efficiency of drag reduction could reach up to 19.3%. Through the analysis of variance, it was concluded that, the air supply is the greatest contribution to the microbubble drag reduction. The contribution of air supply is 59.48%.