Pulmonary Large Cell Neuroendocrine Carcinoma Presenting with Metastatic Brain Tumor of Unknown Origin

以不明原因腦轉移癌為起始表現的肺大細胞神經分泌性癌

陳俊偉(Chun-Wei Chen) ； 邱昭華(Chao-Hua Chiu) ； 周德盈(Teh-Ying Chou) ； 許文虎(Wen-Hu Hsu) ； 彭瑞鵬(Reury-Perng Perng)

《胸腔醫學》 21卷5期 (2006/10) Pp. 462-467

https://doi.org/10.29806/TM.200610.0010

摘要

大細胞神經分泌性癌是一種分化不良、高度的神經內分泌癌且癌性相當惡性。我們報告一位74歲的抽煙男性以有症狀的不明原因腦轉移癌為起始表現，直到三年後才診斷原發的肺大細胞神經分泌性癌。腦轉移瘤以及肺腫瘤皆成功的以手術切除，病患因此有相當不錯的預後。如果只有單純的腦轉移，不明原因腦轉移癌的病患應該積極的治療，定期的術後追蹤有助於早期診斷原發癌，即使是像我們在此所報告的高惡性度肺大細胞神經分泌性癌，也可能因此有較佳的預後。

關鍵字

大細胞神經分泌性癌 ； 腦轉移癌 ； 原發腫瘤未明癌

並列摘要

Large cell neuroendocrine carcinoma (LCNEC) is a poorly differentiated high-grade neuroendocrine tumor with very aggressive behavior. Herein, we report a 74-year-old male smoker who initially presented with a symptomatic metastatic brain tumor of unknown origin (MBUO). Primary pulmonary LCNEC was not diagnosed until 3 years later. Both the metastatic brain tumor and the primary lung cancer were successfully treated by surgical intervention, and the patient had a very favorable outcome. Management of MBUO should be aggressive if patients have only isolated brain metastasis. Periodic re-evaluation after treatment of the brain tumor may help to detect an earlier stage of primary cancer and may result in a better outcome, even in highly aggressive malignancies like LCNEC.

並列關鍵字

large cell neuroendocrine carcinoma ； metastatic brain tumor ； malignancy of unknown origin