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Successful Discontinuation of Secondary Prophylaxis for Histoplasmosis after Highly Active Antiretroviral Therapy

對於愛滋病患的組織徽菌感染在使用高效能抗愛滋病毒藥物後停用次級抗徽菌預防用藥的病例報告

並列摘要


Whether maintenance antifungal prophylaxis against histoplasmosis should be continued life-long in patients with immune restoration after highly active antiretroviral therapy (HAART) remains unclear. We report a case of disseminated histoplasmosis involving the skin, lung, gastrointestinal tract, mesentery, and retroperitoneum in a 33-year-old man with acquired immunodeficiency syndrome. His symptoms improved after use of amphotericin B and itraconazole in addition to ileostomy to relieve the intestinal obstruction. After the start of HAART, he was able to discontinue itraconazole as maintenance therapy without relapse for 24 months.

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