The study was based on a groundwater flow model. The paper has been estimated the groundwater potential pollution in Pingtung Plain with the DRASTIC model. A transport model with MT3D of Processing Modflow has been created to offer the suitable information. The model has been simulated a solute advective process for five years. The concentration information is found by seven observation wells in it. Then the output data would offer FREQ software to estimate the best sampling frequency for monitoring wells. In the results of general and agricultural rank estimation, the highest potential pollution was pointed at Neipu. Meinung. Chishan, Chutien, and Wanluan. The lowest were Kanting and Hsipei Kanting was the overlap of the two estimation results. The best sampling frequency of groundwater quality monitoring ells was one time per month.