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  • 學位論文

利用RNAi抑制EB病毒溶裂期之進行

Inhibition of Epstein-Barr Virus Lytic Cycle by RNA Interference

指導教授 : 蔡錦華

摘要


EB病毒與其他人類皰疹病毒科成員一樣具有兩種不同型態的生活史,包括潛伏期與溶裂期。然而於體外模式中,某些化學藥劑或細胞激素(例如:TPA:12-O-tetradecanoylphorbol-13-acetate、SB:n-sodium butyrate或是TGF-

關鍵字

溶裂期 抑制

並列摘要


EBV(Epstein-Barr virus), like other human herpesviruses, possesses two phases in its life cycle: latent and lytic stages. In vitro, however, EBV can be triggered into lytic cycle in the presence of the chemicals or cytokines, such as 12-O-tetradecanoyl -phorbol-13-acetate(TPA), n-sodium butyrate(SB), or TGF-

並列關鍵字

EBV siRNA lytic cycle

參考文獻


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2. Aviel, S., G. Winberg, M. Massucci, and A. Ciechanover. 2000. Degradation of the Epstein-Barr virus latent membrane protein 1 (LMP1) by the ubiquitin-proteasome pathway. Targeting via ubiquitination of the N-terminal residue. J. Biol. Chem. 275:23491-9.
3. Bargonetti, J., and J. J. Manfredi. 2002. Multiple roles of the tumor suppressor p53. Curr. Opin. Oncol. 14:86-91.
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