電荷可調節之軟性粒子的擴散泳與奈米孔道中之電擴散滲透流

近年來離子濃度梯度被廣泛地應用在醫學、生物領域以及奈米科技相關的應用上。為了瞭解實驗中所發現的特殊現象，具有能進一步描述真實情況的理論模型是必要的。本文的第一個主題中，吾人考慮一表面具有電荷可調節特性的軟性膠體粒子在多離子的電解質溶液中之擴散泳行為。由於軟性膠體粒子可用以模擬各種生物型膠體粒子、採用電荷可調節系統可以有效的模擬出現實環境中膠體粒子的表面特性、以及溶液相中採用相同性高的多離子系統，更可適用於在各種酸鹼狀態下的液相環境，吾人所考慮之問題能夠貼近真實情況進行完整的分析。在第二個主題中，吾人探討了同時施加電場與離子濃度梯度時，在一聯結兩個貯存器之帶電的奈米通道內之電擴散滲透流。由於奈米通道與系統內電雙層間的交互作用，導致特別且複雜的離子濃度極化現象，所獲結果提供了目前用於生物感測的奈米元件設計重要的資訊。吾人的分析，不僅針對實驗中發現的特殊現象提出合理的解釋，且可供研究者在相關實驗參數設定時的參考。

關鍵字

擴散泳；電擴散滲透流；軟球；多離子溶液；奈米孔洞；離子濃度極化

並列摘要

Recently, salt concentration gradient has been widely applied in medicine, biotechnology, and nanotechnology related applications. To better understand several specific and interesting behaviors observed experimentally, establishing a more general and sound theoretical model is necessary and desirable. In the first part of this study, the diffusiophoresis of a soft, charge-regulated particle in a solution containing multiple ionic species is considered. The type of particle considered is widely used to mimic biocolloids, it is capable of simulating closely their charged conditions. Because the solution pH is usually adjusted by introducing acid and base, considering the presence of mulitiple ionic species in the liquid phase is necessary. In the second part of this study, the electrofiffusioosmosis near a solid-state nanopore connecting two large reservoirs is investigated. The interaction between the size of the nanopore and the associated double layer yields profound and interesting ion concentration polarization. The results gathered provide valuable information for the design of nanopore based sensing devices. The model developed also provides necessary theoretical background for experimentalists to interpret their findings.