糖尿病為2018年國人十大死因之一，由於血糖居高不下，易於體內進行梅納反應，產生醣化終產物（Advanced glycation end-products, AGEs），導致許多併發症如阿茲海默症、心血管疾病等，而醣化終產物除了會使糖尿病患者產生相關併發症，也被認為是促使人體老化的影響因子，因此本研究使用文獻指出具抗糖尿病的桃金孃科（嘉寶果、芭樂、蓮霧）與桑科（波羅蜜、無花果、桑葉）植物葉片進行抗醣化實驗，並針對樣品中酚類化合物進行分析。實驗結果顯示，桃金孃科對AGEs生成之半抑制濃度為400-750 ppm，桑科AGEs之IC50為900-1500 ppm，在甲基乙二醛捕獲率IC50上桃金孃科樣品為200-250 ppm，桑科植物則皆大於500 ppm，且將各項實驗經主成分分析及因子分析，並可明顯將不同科植物區分，同時看出桃金孃科具有較佳之抗醣化與抗氧化能力。在樣品各實驗項目相關性分析，由於抗醣化能力與抗氧化能力呈正相關R=0.805-0.969，推測樣品是利用清除形成希夫鹼所釋放的自由基以避免反應性羰基化合物形成達到抗醣化的功效；接著對樣品中的酚酸及類黃酮標準品進行AGEs IC50與甲基乙二醛捕獲率IC50之測定，結果顯示酚酸與類黃酮結構顯著影響其抗醣化能力，並與不飽和鍵結、羥基位置、數量及官能基等有關。

Diabetes is one of the top ten causes of death in Taiwan in 2018. The cause of diabetes is complicate. Due to the high blood sugar, it is easy to undergo Maillard reaction in the body to produce advanced glycation end-products (AGEs), which in turn leads to many complications such as Alzheimer’s disease, cardiovascular disease and human aging. This study is aimed to analyze and discuss some plant leaves, such as Myrtaceae (Jaboticaba, Guava, Wax apple), and Moraceae (Jackfruit, Fig, Mulberry), which has been reported to exhibit the anti-diabetic function. The results showed that the IC50 of AGEs of Myrtaceae is 400-750 ppm, and the Moraceae is 900-1500 ppm; the IC50 of methylglyoxal trapping of Myrtaceae is 200-250 ppm, the Moraceae is more than 500 ppm, and the sample can be separated according to the families through using principal component analysis (PCA) and factor analysis. Since the correlation coefficient between anti-glycation and antioxidant capacity is ranged from 0.805-0.969, it is speculated that the sample performed the anti-glycation effect through scavenge free radical release by formation Schiff base. Subsequent analysis of IC50 in AGEs and methylglyoxal trapping of standard phenolic acids and flavonoids occurred in the sample, by using aminoguanidine as the control group, showed that the structure of phenolic compounds significantly affects the ability of anti-glycation and depended on the unsaturated bonds, the position and number of hydroxyl groups.

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