陳皮為芸香科 (Rutaceae) 常綠小喬木植物橘 (Citrus reticulata) 的成熟果皮，經乾燥陳放後製成。相關研究顯示柑橘果皮中富含的多甲氧基類黃酮 (polymethoxyflavones； PMFs) 具抗氧化、抗發炎、降低膽固醇等活性。在本研究中，將陳皮以甲醇浸泡萃取，得陳皮甲醇粗萃物，經分配萃取得到乙酸乙酯層、正丁醇層及水層萃取物。在抗氧化結果中，顯示乙酸乙酯層萃取物具有活性。將乙酸乙酯層經由管柱層析分離出三十四組分液，進一步以管柱層析、高效能液相層析與再結晶等方法，進行乙酸乙酯層萃取物純化，經由核磁共振光譜分析與文獻比對，共鑑定出十個化合物，包含三個芳香類 (Aromatics)： Vanillin acid、4-Hydroxybenzaldehyde、Ferulic acid；一個檸檬苦素類 (Limonoid)： Limonin； 一個固醇類 (Steroid)： -Sitosterol；一個香豆素類 (Coumarin)：Scoparone；三個黃酮類 (Flavonoids)： 3-Hydroxy-5,6,7,8,3′,4′-hexamethoxyflavone、Retusin、3,3',4',5,6,7,8-Heptamethoxyflavone；一個呋喃類 (Furan)：5-HMF。
關鍵詞：橘、芸香科、管柱層析、抗氧化、多甲氧基類黃酮

Chen pi is oven- or sun-dried peel of Citrus reticulata used as a traditional Chinese medicine. Many studies demonstrated that polymethoxyflavones (PMFs) from citrus peel possess anti-oxidant, anti-inflammatory and lowering cholesterol effects. In this study, oven-dried peels of Citrus reticulata were extracted with methanol (MeOH). The MeOH crude extract was suspended in water and partitioned with ethyl acetate (EA) and n-butanol (n-BuOH) to obtain the EA, n-BuOH and water layers of Citrus reticulata peels. In the preliminary antioxidant assays, the EA layer of Citrus reticulata peels showed anti-oxidant activity. The EA layer was separated into thirty-four fractions by column chromatography. The fractions were then purified by repeated column chromatography, high performance liquid chromatography (HPLC) and recrystallization to obtain ten compounds, including three aromatics: vanillic acid, 4-hydroxybenzaldehyde, ferulic acid; one limonoid: Limonin; one steroid: -sitosterol; three flavonoids: 3-hydroxy-5,6,7,8,3′,4′-hexamethoxyflavone, Retusin, 3,3',4',5,6,7,8-heptamethoxyflavone; and one furan: 5-HMF. Their structures were elucidated by comparison of their spectral data with related literature values.
Keywords： Citrus reticulata, Rutaceae, column chromatography, anti-oxidant, polymethoxyflavones

林萱淇、賴軍諺、郭宗甫. 2011. 藥用植物陳皮之療效. 中華傳統獸醫學
會會刊， 15(2): 127-134.

鄭鈺女 2015 探討5-去甲基川陳皮素於動物實驗與細胞實驗中抗發炎與抗腸癌腫瘤生成之功效。取自 https://hdl.handle.net/11296/hp47af

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