This study aims to construct a model of instruction and assessment for the communication and leadership class. The participants were 66 students of a medical university in southern Taiwan. Data were collected from questionnaires and students' reports. Both qualitative and quantitative methods were employed to analyze the data. The results showed that(1)More than 84% of the students were willing to take the role as a leader after finishing this class.(2)The most favorite topic was the final group presentation(3)In addition to lectures, small group discussion was students' favorite class activity. It is hoped that the conclusions of this study can serve as a useful reference for instructors of general education courses for research or teaching purposes.