Antimutagenic Potential of Graptopetalum paraguayense E. Walther Extracts

石蓮萃取物之抗致突變活性評估

周淑姿(Su-Tze Chou) ； 陳淑茹(Shu-Ju Chen) ； 葉貞吟(Jan-Ying Yeh) ； 鍾雲琴(Yun-Chin Chung)

《臺灣農業化學與食品科學》 43卷5期 (2005/10) Pp. 349-357

https://doi.org/10.6578/TJACFS.2005.044

摘要

石蓮(Graptopetalum paroguayense E. Walther)根據民間傳用具有許多醫療功效，然其真正的生理機能之文獻探討幾乎闕如。本研究主要目的是將石蓮以水(GWE)、50%乙醇(GE50)或95%乙醇(GE95)三種不同溶劑萃取後，以安姆試驗評估石蓮萃取物之抗致突變能力。試驗結果顯示石蓮萃取物於所測試的濃度範圍內，對Salmonella typhimurium TA97、TA98、TA100及TA102無致突變性。添加S9 mix作為模擬生物體內環境時，所有萃取物對於致突變劑2-aminofluorene (2-AF)及2-aminoanthracene (2-AA)所誘發之突變具有高達100%之抑制效果。

關鍵字

抗致突變 ； 石蓮 ； 水萃取物 ； 50%乙醇萃取物 ； 95%乙醇萃取物 ； 安姆試驗

並列摘要

According to the archaic Chinese prescription, Graptopetalum paraguayense E. Walther is used for medication purpose; however, no literature on its biophysical functions is presently available. This study was aimed to evaluate the antimutagenicity activities of water (GWE), 50% ethanolic (GE50), and 95% ethanolic (GE95) extracts of Graptopetalum paraguayense. The mutagenic and antimutagenic properties of the three extracts were investigated using Ames test. The results showed that all the extracts had no-mutagenicity effect toward all tester strains (Salmonella typhimurium TA97, TA98, TA100, TA102, and TA1535). All tested extracts had marked 100% inhibition effect against the mutagenicity of the diagnostic mutagens, 2-aminofluorene (2-AF) and 2-aminoanthracene (2-AA), in all tester strains with the S9 mix system.

並列關鍵字

Antimutagenesis ； Graptopetalum paraguayense E. Walther ； Water extract ； 50% Ethanolic extract ； 95% Ethanolic extract ； Ames test