大豆異黃酮的補充對糖尿病前期肥胖女性體組成、血糖、血脂和性荷爾蒙之影響

Effects of isoflavones supplement on body composition, blood sugar, blood lipids and sex hormone profiles in prediabetes obese women

學怡君(Yi-Chun Hsueh)

指導教授 ： 簡怡雯

臺北醫學大學/公共衛生暨營養學院/保健營養學研究所/碩士(2011年)

https://doi.org/10.6831/TMU.2011.00026

摘要

糖尿病在全世界許多國家已經成為嚴重的健康問題，篩檢並管控好糖尿病前期的狀況可以減少往後罹患糖尿病的風險。此外，研究發現女性罹患糖尿病的風險較男性高，可能與雌激素作用有關連，而大豆異黃酮結構類似於雌激素，可以和雌激素接受器結合而影響身體代謝。本次實驗目的是以大豆異黃酮介入未停經、血糖異常且肥胖的女性探討對體組成、血糖、血脂和性賀爾蒙之影響。實驗總共招收14位受試者，隨機分成控制組和實驗組每組各7人，實驗組給予每天200毫克大豆異黃酮，控制組給予安慰劑，連續介入12週。所有受試者在實驗第0、4、8和12週收集體位測量資料、血液生化資料、活動量資料和飲食資料，此外在第0週和第12週進行葡萄糖耐受性試驗。結果發現，實驗組在實驗後之體重、BMI、體脂肪百分率和血壓較第0週有下降之趨勢，且HbA1c較第0週有下降之趨勢。實驗組之第0週和第12週總睪固酮濃度顯著較控制較高(p＜0.05)，而大豆異黃酮介入12週，顯著下降實驗組總睪固酮濃度(p＜0.05)。因此，大豆異黃酮之介入，可顯著改善總睪固酮濃度，具輕微上升SHBG濃度、輕微下降空腹血糖和血脂濃度之作用。

關鍵字

第2型糖尿病 ； 糖尿病前期 ； 大豆異黃酮 ； 性荷爾蒙

並列摘要

Diabetes mellitus (DM) has become a serious public health problem in many countries. To identify and well management with prediabetes mellitus can reduce risk to develop diabetes. Incidence of women with DM is higher than men. It may associate with estradiol. Isoflavones are structurally similar to estradiol and able to influence metabolism through estrogen receptors. The aim of this study was to determine whether supplement with isoflavones affected body composition, blood sugar, lipid profile, and sex hormone on premenopausal, abnormal glucose homeostasis, and BMI ≧24.We assigned 14 participants that ramdomize to placebo or isoflavone (200mg) group for 12 weeks. All participants collected anthropometry, biochemical analysis, physical activity and diet record at the 0, 4, 8, and 12 weeks. Oral glucose tolerance tests were performed at the beginning and the end of trial. Statistical analyses were performed with SAS software. Result showed that isoflavone group had trend down on weight, BMI, body fat percentage and blood pressure at 12 weeks. In the total tesetosterone level, isoflavone group was significantly highered compared with placebo group (p＜0.05). After 12 weeks, isoflavone group was significantly decreased total tesetosterone level compared with baseline. Therefore, isoflavones intervention would improve total tesetosterone level to women, and could ameliorate SHBG level, fasting glucose and blood lipid.

並列關鍵字

diabetes mellitus ； prediabetes mellitus ； isoflavones ； sex hormone

參考文獻

行政院衛生署 (2010) 國人十大死因。

行政院衛生署 (2009) 國民營養健康狀況變遷調查研究。

(2009) Standards of medical care in diabetes--2009. Diabetes Care 32 Suppl 1, S13-61.

Abdul-Ghani MA & DeFronzo RA (2009) Pathophysiology of prediabetes. Curr Diab Rep 9, 193-199.

Anderson JW & Hoie LH (2005) Weight loss and lipid changes with low-energy diets: comparator study of milk-based versus soy-based liquid meal replacement interventions. J Am Coll Nutr 24, 210-216.