This Thesis aims to investigate the historical evolution of the evangelizing missions of the Holy See in China and to know the pattern of relations between China and the Holy See, in the context of China's religious political control and its impacts on the evangelist missions regarding Religious Liberty and the evangelizing doctrine of the Holy See. This Thesis uses historical and documentary analysis as a methodology, and its purpose is to be useful for people who have an interest in the Human Right to religious freedom in the context of the relations between the Holy See and the Republic of China (Taiwan) and the People's Republic of China.