The strong tragic implication is a very significant artistic style of the May 4th female literature. The tragedy of the times, writers' own tragic experience, and writers' sense of mission and awareness of unexpected development are the internal reasons for the formation of the strong tragic implication. From the perspective of the fate of women, this paper explores the specific performance of the tragic implications of the May 4th female literature, which can be roughly divided into two aspects: objective (oppression and squeeze imposed on women by social environment) and subjective (backwardness of women's own consciousness). Taking seven short story collections of seven May 4th female writers as research objects, this paper makes a detailed analysis of "women's illness and death" in the novels, and finds that the description of women's illness and death in May 4th female literature is very common. The illness and death of the characters in May 4th female writers' novels, especially the female ones, are mainly caused by the spiritual factors. Among the novels written by the May 4th female writers, Lu Yin's and Shi Pingmei's have the strongest tragic implication.