This is a multiple trauma case of brain contusion with intracranial hemorrhage and loss of consciousness, thoraxic rib and right tibial fracture, as well as right ulna-radial and both femoral open fracture. The patient was admitted via emergency and received craniotomy, right thigh debridement and fixed operation of bone fracture. Unfortunately he suffered from infectious complication with high fever and osteomyelitis in post-operation. The patient’s condition was stabilized under combined treatment of Chinese medicine and Western Medicine. He was admitted and discharged hospitalization for three times. The recovery condition of bone fracture in postoperative rehabilitation and acupuncture treatment was very well. The complicated osteomyelitis also had complete remission.