多羥基吡咯和哌啶生物鹼的化合物結構吸引很多的化學合成家的注意，因其驚人的生物活性和具有作為藥物的的潛力，特別是在治療癌症、糖尿病和病毒的傳染病過程中作為醣水解酵素抑制劑。
因此發展新的方法合成多羥基吡咯和哌啶的化合物是相當的重要，尤其是此類環形結構的掌性衍生物。
在這論文中，我們利用D-木糖為起始物，發展新的合成方法，且有效率的合成多羥基吡咯和哌啶衍生物，以評估其生物活性。

The chiral polyhydroxy alkaloids have attracted considerable attention in organic synthesis owing to their remarkable biological properties and their potential as pharmaceuticals, especially, to serve as glycosidase inhibitors in treatment of cancers, diabetes and viral infections.
The development of new methods for the synthesis of pyrrolidine- or piperidine-based compounds is therefore of considerable importance, particularly for the approaches leading to chiral derivatives of these ring skeletons.
In this thesis, we have developed new and efficient synthetic protocols to prepare various polyhydroxylated pyrrolidine and piperidine-based alkaloids from D-xylose to evaluate their biological activities.

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