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研究生: 邱麗倫
論文名稱: 低磁場下的Fe304-Anti CRP之磁鬆弛研究
The Research of Magnetic Relaxation in Fe304-Anti CRP at Low Magnetic Field
指導教授: 楊鴻昌
Yang, Hong-Chang
洪姮娥
Horng, Herng-Er
學位類別: 碩士
Master
系所名稱: 光電工程研究所
Graduate Institute of Electro-Optical Engineering
論文出版年: 2012
畢業學年度: 100
語文別: 中文
論文頁數: 43
中文關鍵詞: 低磁場
論文種類: 學術論文
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  • 我們將預先極化技術以及超導量子干涉元件(Superconducting quantum interference device, SQUID)應用於低磁場核磁共振系統上。重新設計預先極化磁場線圈,使得預極化磁場提高到780高斯,10 ml水量的線寬為0.9 Hz,訊雜比為95。在磁性奈米粒子之磁鬆弛量測方面,固定Fe3O4-Anti CRP濃度下,縱向鬆弛時間T1與橫向鬆弛時間T2隨著溫度上升而變長,固定溫度下,縱向鬆弛時間T1與橫向鬆弛時間T2隨著Fe3O4-Anti CRP濃度增加而變短,最後與未標靶之磁流體做比較,Fe3O4-Anti CRP的1/T1與1/T2皆大於純磁流體的1/T1與1/T2。

    第一章 緒論 1 第二章 實驗原理 2 2-1 低磁場之核磁共振介紹 2 2-2 核磁共振原理 3 2-2-1 核磁共振 3 2-1-2 縱向鬆弛與橫向鬆弛 5 2-3 NMR於磁性標記免疫檢測之應用 11 2-4 C-反應蛋白(C-reactive Protein, CRP)簡介 13 第三章 實驗架構 14 3-1 系統架構介紹 14 3-2 預先極化線圈 (Pre-polarization coil) 16 3-3 冷卻水系統 19 第四章 實驗結果與數據討論 20 4-1不同濃度Fe3O4-Anti CRP之T1量測 20 4-1-1 568高斯下之T1量測 20 4-1-2 1高斯下之T1量測 24 4-2不同濃度Fe3O4-Anti CRP之T2量測 27 4-3不同濃度Fe3O4-Anti CRP之線寬變化 33 4-3-1利用柯西-勞倫茲分布特性計算線寬 33 4-3-2 線寬變化之量測 35 4-4 Fe3O4-Anti CRP與純磁流體之T1與T2比較 38 第五章 結論 40 參考文獻 41

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