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| 研究生： |
林泓宇 |
|---|---|
| 論文名稱： |
含鎳超氧化物歧化酶擬態化合物之合成 Synthesis of Mimics for Nickel Superoxide Dismutase |
| 指導教授： | 李位仁 |
| 學位類別： |
碩士 Master |
| 系所名稱： |
化學系 Department of Chemistry |
| 論文出版年： | 2018 |
| 畢業學年度： | 106 |
| 語文別： | 中文 |
| 論文頁數： | 59 |
| 中文關鍵詞： | 鎳錯合物 、含鎳超氧化物歧化酶 、擬態化合物 |
| 英文關鍵詞： | Ni Complexs, NiSOD, Mimics |
| DOI URL： | http://doi.org/10.6345/THE.NTNU.DC.059.2018.B05 |
| 論文種類： | 學術論文 |
| 相關次數： | 點閱：45 下載：0 |
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本研究承接本實驗室所開發出的鎳超氧岐化酶擬態化合物2,6-bis(((S)-2-(diphenyl-hydroxymethyl)-1pyrrolidinyl)methyl)pyridine (H2BDPP)系列配基，將苯環區進行修飾得到H2BDP2-dioP。此配基在進行去質子化後與[Ni(CH3CN)6](ClO4)2反應得到的二價錯合物Ni(BDP2-dioP)，可跟氧化劑反應得到三價鎳的EPR光譜，從UV-vis光譜上也可以看到此三價鎳錯合物與超氧化鉀反應還原成二價NiBDP2-dioP的過程。除了如同其他NiBDPP系列錯合物一般有形成鎳三價錯合物的特性。在不破壞配位中心的條件下，Ni(BDP2-dioP)可以直接進行官能基轉換形成醛基修飾鎳二價錯合物NiBDPCHOP。基於醛類易氧化還原與跟其他官能基縮合等特點，提供Ni(BDPCHOP)進一步進行官能基修飾，和接到胜肽鏈上合成人工酵素的潛力
Based on the ligand 2,6-bis(((S)-2-(diphenyl-hydroxymethyl)-1-pyrrolidinyl)methyl)pyridine (H2BDPP) previously synthesized in our lab, this work has focused on studying that how to change a functonal group to another on the ligand in the mimics of NiSOD. Therefore, we have designed and synthsized a protected ligand H2BDP2-dioP. After deprotonating the ligands and reacting with [Ni(CH3CN)6](ClO4)2, the complexe Ni(BDP2-dioP) (1) have been prepared. Complex 1 can be oxided by FcPF6 to [Ni(BDP2-dioP)](PF6) (3), which has been demonstrated by the EPR diagrams to NiIII species. The electron absorption spectroscopy and X-ray crystallography indicate that reaction of 3 with KO2 produce original complexes 1 without deprotection of dioxolane group. The dioxolane group of complex 1 is stable unless it has been deprotected by FeCl3 to Ni(BDPCHOP) (2), without side reaction and demetalation.
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