簡易檢索 / 詳目顯示

研究生: 莊泰源
Chuang, Tai Yuan
論文名稱: 中藥配方顆粒劑B307對運動與代謝的影響
Effects of Chinese herbal formulation granules B307 on exercise and metabolism
指導教授: 吳忠信
Wu, Chung-Hsin
口試委員: 林貴福
Lin, Kuei-Fu
丁詩同
Ding, Shih-Torng
鄭劍廷
Chien, Chiang-Ting
林豊益
Lin, Li-Yih
吳忠信
Wu, Chung-Hsin
口試日期: 2021/08/03
學位類別: 博士
Doctor
系所名稱: 生命科學系
Department of Life Science
論文出版年: 2021
畢業學年度: 109
語文別: 中文
論文頁數: 82
中文關鍵詞: 中草藥配方顆粒劑運動表現代謝功能心肺運動功能障礙
英文關鍵詞: Chinese herbal medicine, formulated granules, sports performance, metabolic function
研究方法: 實驗設計法
DOI URL: http://doi.org/10.6345/NTNU202101708
論文種類: 學術論文
相關次數: 點閱:34下載:0
分享至:
查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報
  • 論文目錄 II 圖表次 V 中文摘要 VI ABSTRACT VII 第壹章 緒論 1 第一節 研究背景 1 第二節 研究動機 3 第三節 研究目的 6 第貳章 文獻探討 7 第一節 中醫藥科學化之相關文獻 7 第二節 科學中藥複方B307之相關文獻 8 第三節 耗竭運動後所造成的急性發炎反應與中藥對清除自由基之相關文獻 10 第四節 中藥增補對耗竭運動影響之相關文獻 12 第五節 甲狀腺疾病與中西藥對其治療之相關文獻 14 第叁章 材料與方法 16 第一節 細胞與動物實驗設計 16 第二節 中藥配方顆粒劑B307之製備與成分分析 17 第三節 神經細胞與心肌細胞之培養 18 第四節 神經細胞放電活動之紀錄 19 第五節 神經細胞與心肌細胞鈣離子流之紀錄 20 第六節 實驗動物皮下微循環血流之紀錄 21 第七節 鴿子離體胸大肌收縮力量之紀錄 22 第八節 大鼠去甲狀腺手術與體重變化之紀錄 23 第九節 大鼠TSH、T3、T4荷爾蒙與ROS之檢測 23 第十節 大鼠心臟功能之檢測 24 第十一節 中藥B307處理對去甲狀腺大鼠VO2、VCO2、呼吸商影響之檢測 26 第十二節 統計與資料分析 26 第肆章 實驗結果 27 第一節 中藥B307的3D高效液相層析化學指紋圖譜與氣相層析質譜儀(GC-MS)分析 27 第二節 中藥B307促進SH-SY5Y神經細胞之電位活動 27 第三節 中藥B307促進SH-SY5Y神經細胞與H9c2心肌細胞之胞內鈣離子流 28 第四節 中藥B307促進小鼠之皮下微循環血流 29 第五節 中藥B307促進鴿子離體胸大肌之收縮力量 29 第六節 中藥B307緩解去甲狀腺大鼠體重之異常減輕 30 第七節 中藥B307對甲狀腺大鼠TSH、T3、T4荷爾蒙之影響 31 第八節 中藥B307緩解去甲狀腺大鼠血液之ROS 31 第九節 中藥B307對去甲狀腺大鼠血流與心臟射血功能之影響 32 第十節 中藥B307對去甲狀腺大鼠VO2、VCO2、呼吸商之影響 33 第伍章 討論 34 第一節 中藥B307對神經系統之影響 34 第二節 中藥B307對骨骼肌與心肌之影響 35 第三節 中藥B307對運動代謝之影響 36 第陸章 結論 41 參考文獻 43 實驗圖表 59

    一、中文參考文獻
    田安然(2017)抗發炎中草藥之開發應用與機轉,國立臺灣師範大學生命科學系博士論文61-63。
    余依婷、鄭慧文(2012)台灣中藥科技發展史,鄭氏藥學文教基金會,52-139。
    吳宮頡(2019)一條根萃取物活性成分改善環磷醯胺誘導膀胱功能障礙與病理機制之大鼠模式,國立臺灣師範大學生命科學系博士論文31-33。
    徐任生(1990)丹參,生物學及其應用,科學出版社。
    張步桃(2004)看中醫如何辨證論治妙手回春,張步桃治大病 ,遠流.
    周福波(2006)麥門冬的藥理作用與研究進展,牡丹江醫學院學報,27(3),69-70。
    陳志明(2008)丹參的奇效,商周出版。
    陳凌熔(2015)訓練合併補充鹿茸酒精萃取物對運動表現及疲勞之影響,國立體育大學運動科學研究所碩士論文,1-60。
    陳麗雯(2021)牛樟芝子實體對四氯化碳誘導慢性肝損傷之功效,國立臺灣師範大學生技醫藥產業碩士學位學程碩士論文。
    郭婕、楊曉琪、程一雄、李寧遠(2006),中藥刺五加對人體抗疲勞功能之影響,中醫藥雜誌,17(3),95-102。
    梁健成、蔡琦、陳正哲、黃克峰、王銘富、賴雅琪、官常慶(2007)中草藥抗氧化作用測定,美容科技學刊,4(1),121-128。
    張嘉珍(2005)增補複方炙甘草湯對單次衰竭運動後血液脂質和氧化壓力指標的影響,臺灣師範大學體育學系學位論文,1-59。
    湯德瑋(2013)金線蓮對小鼠抗疲勞與提升運動表現之影響,國立體育運動大學運動健康科學學院碩士論文,1-42。
    維基百科編者(2021)中藥,維基百科:https://zh.wikipedia.org/w/index. php ? title=%E4%B8%AD%E8%8D%AF&oldid= 66443025。
    維基百科編者(2021)中醫學,維基百科:https://zh.wikipedia.org/w/index.php?title=%E4%B8%AD%E5%8C%BB %E5%AD%A6&oldid=66403934
    維基百科編者(2021)元亨療馬集,維基百科:https://zh.wikipedia.org/w/index.php?title=Special:%E5%BC%95%E7%94%A8%E6%AD%A4%E9%A1%B5%E9%9D%A2&page=%E5%85%83%E4%BA%A8%E7%96%97%E9%A9%AC%E9%9B%86&id=63922376&wpFormIdentifier=titleform
    維基百科編者(2021)五味子,維基百科: https://zh.wikipedia.org/w/index.php?title=%E4%BA%94%E5%91%B3% E5%AD%90&oldid=66128743
    維基百科編者(2021)杜聰明,維基百科:https://zh.wikipedia.org/w/index.php?title=%E6%9D%9C%E8%81%B0 %E6%98%8E&oldid=66419370
    維基百科編者(2021)科學中藥,維基百科:https://zh.wikipedia.org/w/index.php?title=%E7%A7%91%E5%AD%B8 %E4%B8%AD%E8%97%A5&oldid=63204517
    維基百科編者(2021)孫思邈,維基百科:https://zh.wikipedia.org/w/index.php?title=%E5%AD%99%E6%80%9D% E9%82%88&oldid=66164307
    維基百科編者(2021)傷寒雜病論,維基百科:https://zh.wikipedia.org/w/index.php?title=%E5%82%B7%E5%AF%92%E9%9B%9C%E7%97%85%E8%AB%96&oldid=65275287
    維基百科編者(2021)藥用植物科學中藥,維基百科:https://zh.wikipedia.org/w/index.php?title=%E8%8D%AF%E7%94% A8%E6%A4%8D%E7%89%A9&oldid=64681443
    臺灣中藥典編修委員會(2018)臺灣中藥典第三版,衛生福利部。
    謝磊、李由、劉新民、陳善慶、王克柱、陳怡西、王琼(201 6)小鼠游泳耐力實驗系統的建立與紅景天緩解疲勞作用的驗證,中國比較醫學雜誌,26(5),71-76。
    盧俊義(1994)許鴻源博士口述自傳,許氏基金會。
    鄒軍、李麗輝、江岩、楊杰、秦淑娟、董洁瓊(2012)中藥生脈飲對女子散打運動員夏訓期體能與免疫功能的影響,中國運動醫學雜誌,31:113-118。
    Wikisource編者、張元素(2019)醫學啟源,Wikisource:https://zh.wikisource.org/w/index.php?title=%E9%86%AB%E5%AD%B8%E5%95%9F%E6%BA%90&oldid=1552673.
    Wikisource編者、李東垣(2019)內外傷辨惑論,Wikisource:https://zh.wikisource.org/w/index.php?title=%E5%85%A7%E5%A4%96%E5%82%B7%E8%BE%A8%E6%83%91%E8%AB%96&oldid=1966672.

    二、英文參考文獻
    Andrade FH, Reid MB, Allen DG, Westerblad H. Effect of hydrogen peroxide and dithiothreitol on contractile function of single skeletal muscle fibres from the mouse. J Physiol. 1998 Jun 1;509 ( Pt 2)(Pt 2):565-75. doi: 10.1111/j.1469-7793.1998.565bn.x. PMID: 9575304; PMCID: PMC2230964.
    Albouaini K, Egred M, Alahmar A, Wright DJ. Cardiopulmonary exercise testing and its application. Heart. 2007 Oct;93(10):1285-92. doi: 10.1136/hrt.2007.121558. PMID: 17890705; PMCID: PMC2000933.
    Ahn K. The worldwide trend of using botanical drugs and strategies for developing global drugs. BMB Rep. 2017 Mar;50(3):111-116. doi: 10.5483/bmbrep.2017.50.3.221. PMID: 27998396; PMCID: PMC5422022.
    Baldissarelli J, Pillat MM, Schmatz R, Cardoso AM, Abdalla FH, de Oliveira JS, Polachini CRN, Casali E, Bornemann CP, Ulrich H, Morsch VM, Schetinger MRC. Post-thyroidectomy hypothyroidism increases the expression and activity of ectonucleotidases in platelets: Possible involvement of reactive oxygen species. Platelets. 2018 Dec;29(8):801-810. doi: 10.1080/09537104.2017.1361017. Epub 2017 Nov 1. PMID: 29090621.
    Bengel FM, Nekolla SG, Ibrahim T, Weniger C, Ziegler SI, Schwaiger M. Effect of thyroid hormones on cardiac function, geometry, and oxidative metabolism assessed noninvasively by positron emission tomography and magnetic resonance imaging. J Clin Endocrinol Metab. 2000 May;85(5):1822-7. doi: 10.1210/jcem.85.5.6520. PMID: 10843159.
    Biondi B, Palmieri EA, Lombardi G, Fazio S. Effects of subclinical thyroid dysfunction on the heart. Ann Intern Med. 2002 Dec 3;137(11):904-14. doi: 10.7326/0003-4819-137-11-200212030-00011. PMID: 12458990.
    Chen XC, Zhu YG, Zhu LA, Huang C, Chen Y, Chen LM, Fang F, Zhou YC, Zhao CH. Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress. Eur J Pharmacol. 2003 Jul 18;473(1):1-7. doi: 10.1016/s0014-2999(03)01945-9. PMID: 12877931.
    Chen YC, Jinn TR, Chung TY, Li FY, Fan RJ, Tzen JT. Magnesium lithospermate B extracted from Salvia miltiorrhiza elevates intracellular Ca(2+) level in SH-SY5Y cells. Acta Pharmacol Sin. 2010 Aug;31(8):923-9. doi: 10.1038/aps.2010.102. PMID: 20686517; PMCID: PMC4007822.
    Chien CT, Fan SC, Lin SC, et al. Glucagon-like peptide-1 receptor agonist activation ameliorates venous thrombosis-induced arteriovenous fistula failure in chronic kidney disease. Thromb Haemost. 2014; 112(5):1051–1064.
    Chiu JH, Wang JC, Lui WY, Wu CW, Hong CY. Effect of magnolol on in vitro mitochondrial lipid peroxidation and isolated cold-preserved warm-reperfused rat livers. J Surg Res 1999: 82: 11-624
    Choksi NY, Jahnke GD, St Hilaire C, Shelby M. Role of thyroid hormones in human and laboratory animal reproductive health. Birth Defects Res B Dev Reprod Toxicol. 2003 Dec;68(6):479-91. doi: 10.1002/bdrb.10045. PMID: 14745982.
    Chuang TY, Lien CY, Tsai YC, Lin KF, Hsu CH, Wu WJ, Su LY, Lu CW, Wu CH. Oral treatment with the Chinese herbal supplements B307 enhances muscle endurance of ICR mice after exhaustive swimming via suppressing fatigue, oxidative stress, and inflammation. Food Sci Nutr. 2020 May 19;8(7):3682-3691. doi: 10.1002/fsn3.1652. PMID: 32724631; PMCID: PMC7382157.
    Dos Reis IGM, Martins LEB, de Araujo GG, Gobatto CA. Forced Swim Reliability for Exercise Testing in Rats by a Tethered Swimming Apparatus. Front Physiol. 2018 Dec 19;9:1839. doi: 10.3389/fphys.2018.01839. PMID: 30618844; PMCID: PMC6305944.
    Fuster-Muñoz E, Roche E, Funes L, Martínez-Peinado P, Sempere JM, Vicente-Salar N. Effects of pomegranate juice in circulating parameters, cytokines, and oxidative stress markers in endurance-based athletes: A randomized controlled trial. Nutrition. 2016 May;32(5):539-45. doi: 10.1016/j.nut.2015.11.002. Epub 2015 Dec 7. PMID: 26778544.
    Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann N Y Acad Sci. 2006 May;1067:10-21. doi: 10.1196/annals.1354.003. PMID: 16803965.
    Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, Braverman LE. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002 Feb;87(2):489-99. doi: 10.1210/jcem.87.2.8182. PMID: 11836274.
    Hsu CC, Ho MC, Lin LC, Su B, Hsu MC. American ginseng supplementation attenuates creatine kinase level induced by submaximal exercise in human beings. World J Gastroenterol. 2005 Sep 14;11(34):5327-31. doi: 10.3748/wjg.v11.i34.5327. PMID: 16149140; PMCID: PMC4622803.
    Hsu CH, Wang SE, Lin CL, Hsiao CJ, Sheu SJ, Wu CH. Neuroprotective Effects of the Herbal Formula B401 in Both Cell and Mouse Models of Alzheimer's Disease. Evid Based Complement Alternat Med. 2016;2016:1939052. doi: 10.1155/2016/1939052. Epub 2016 Sep 28. PMID: 27761145; PMCID: PMC5059538.
    Hueston WJ, Pearson WS. Subclinical hypothyroidism and the risk of hypercholesterolemia. Ann Fam Med. 2004 Jul-Aug;2(4):351-5. doi: 10.1370/afm.79. PMID: 15335135; PMCID: PMC1466694.
    Kanter MM, Nolte LA, Holloszy JO. Effects of an antioxidant vitamin mixture on lipid peroxidation at rest and postexercise. J Appl Physiol (1985). 1993 Feb;74(2):965-9. doi: 10.1152/jappl.1993.74.2.965. PMID: 8458821.
    Kaçmaz M, Atmaca M, Arslan A, Demir H, Özbay MF. Oxidative stress in patients with thyroidectomy and thyroparathyroidectomy under replacement therapy. Endocrine. 2015 Feb;48(1):227-32. doi: 10.1007/s12020-014-0270-6. Epub 2014 Apr 24. PMID: 24760660.
    Kubli S, Waeber B, Dalle-Ave A, Feihl F. Reproducibility of laser Doppler imaging of skin blood flow as a tool to assess endothelial function. J Cardiovasc Pharmacol. 2000;6:640–648.
    Lam FF, Yeung JH, Kwan YW, Chan KM, Or PM. Salvianolic acid B, an aqueous component of danshen (Salvia miltiorrhiza), relaxes rat coronary artery by inhibition of calcium channels. Eur J Pharmacol. 2006 Dec 28;553(1-3):240-5. doi: 10.1016/j.ejphar.2006.09.030. Epub 2006 Sep 23. PMID: 17054942.
    Lee JS, Song JH, Sohn NW, Shin JW. Inhibitory effects of ginsenoside Rb1 on neuroinflammation following systemic lipopolysaccharide treatment in mice. Phytother Res. 2013 Sep;27(9):1270-6. doi: 10.1002/ptr.4852. Epub 2012 Oct 8. PMID: 23042638.
    Li S, Chen Z (2018) Evaluation of antifatigue effects of 20(s)-ginsenoside Rg3 in forced swimming mice. Indian Journal of Pharmaceutical Sciences, 80: 510-515.
    Liang D, Zhang M. The thinking on TCM differential treatment of congestive heart failure. J Tradit Chin Med. 2000 Mar;20(1):44-7. PMID: 10921172.
    Lien CY, Chuang TY, Hsu CH, Lin CL, Wang SE, Sheu SJ, Chien CT, Wu CH (2015) Oral treatment with the herbal formula B307 alleviates cardiac toxicity in doxorubicin-treated mice via suppressing oxidative stress, inflammation, and apoptosis. Onco Targets Ther. 8:1193-210. doi: 10.2147/OTT.S82936. PMID: 26060405; PMCID: PMC4454207.
    Li, “Progress of research in Chinese medicine for hyperthyroidism,” Journal of Chinese Medicine Information, vol. 5, no. 10, pp. 15-16, 1998.
    Lin CL, Wang SE, Hsu CH, Sheu SJ, Wu CH. Oral treatment with herbal formula B307 alleviates cardiac failure in aging R6/2 mice with Huntington's disease via suppressing oxidative stress, inflammation, and apoptosis. Clin Interv Aging. 2015 Jul 20;10:1173-87. doi: 10.2147/CIA.S86493. PMID: 26229452; PMCID: PMC4516205.
    Lin HF, Tung K, Chou CC, Lin CC, Lin JG, Tanaka H. Panax ginseng and salvia miltiorrhiza supplementation abolishes eccentric exercise-induced vascular stiffening: a double-blind randomized control trial. BMC Complement Altern Med. 2016 Jun 6;16:168. doi: 10.1186/s12906-016-1139-4. PMID: 27266702; PMCID: PMC4895816.
    Lin WM, Zhang YM, Moldzio R, Rausch WD. Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture. J Neural Transm Suppl. 2007;(72):105-12. doi: 10.1007/978-3-211-73574-9_13. PMID: 17982883.
    Li ZM, Xu SW, Liu PQ. Salvia miltiorrhiza Burge (Danshen): a golden herbal medicine in cardiovascular therapeutics. Acta Pharmacol Sin. 2018 May;39(5):802-824. doi: 10.1038/aps.2017.193. Epub 2018 Apr 26. PMID: 29698387; PMCID: PMC5943903.
    Malaguti M, Angeloni C, Garatachea N, Baldini M, Leoncini E, Collado PS, Teti G, Falconi M, Gonzalez-Gallego J, Hrelia S. Sulforaphane treatment protects skeletal muscle against damage induced by exhaustive exercise in rats. J Appl Physiol (1985). 2009 Oct;107(4):1028-36. doi: 10.1152/japplphysiol.00293.2009. Epub 2009 Aug 27. PMID: 19713431.
    Margonis K, Fatouros IG, Jamurtas AZ, Nikolaidis MG, Douroudos I, Chatzinikolaou A, Mitrakou A, Mastorakos G, Papassotiriou I, Taxildaris K, Kouretas D. Oxidative stress biomarkers responses to physical overtraining: implications for diagnosis. Free Radic Biol Med. 2007 Sep 15;43(6):901-10. doi: 10.1016/j.freeradbiomed.2007.05.022. Epub 2007 May 23. Erratum in: Free Radic Biol Med. 2008 Jun 15;44(12):2058. PMID: 17697935.
    McArdle WD, Montoye HJ. Reliability of exhaustive swimming in the laboratory rat. J Appl Physiol. 1966 Jul;21(4):1431-4. doi: 10.1152/jappl.1966.21.4.1431. PMID: 5916692.
    Miao X, Xiao B, Shui S, Yang J, Huang R, Dong J. Metabolomics analysis of serum reveals the effect of Danggui Buxue Tang on fatigued mice induced by exhausting physical exercise. J Pharm Biomed Anal. 2018 Mar 20;151:301-309. doi: 10.1016/j.jpba.2018.01.028. Epub 2018 Jan 31. PMID: 29413978.
    Michailidis Y, Jamurtas AZ, Nikolaidis MG, Fatouros IG, Koutedakis Y, Papassotiriou I, Kouretas D. Sampling time is crucial for measurement of aerobic exercise-induced oxidative stress. Med Sci Sports Exerc. 2007 Jul;39(7):1107-13. doi: 10.1249/01.mss.0b013e318053e7ba. PMID: 17596778.
    Mihm MJ, Amann DM, Schanbacher BL, Altschuld RA, Bauer JA, Hoyt KR. Cardiac dysfunction in the R6/2 mouse model of Huntington's disease. Neurobiol Dis. 2007 Feb;25(2):297-308. doi: 10.1016/j.nbd.2006.09.016. Epub 2006 Nov 27. PMID: 17126554; PMCID: PMC1850107.
    Mullur R, Liu YY, Brent GA. Thyroid hormone regulation of metabolism. Physiol Rev. 2014 Apr;94(2):355-82. doi: 10.1152/physrev.00030.2013. PMID: 24692351; PMCID: PMC4044302.
    Nagao H, Imazu T, Hayashi H, Takahashi K, Minato K. Influence of thyroidectomy on thyroxine metabolism and turnover rate in rats. J Endocrinol. 2011 Jul;210(1):117-23. doi: 10.1530/JOE-10-0484. Epub 2011 Apr 8. PMID: 21478227.
    Ogawa H, Shinoda T, Cornelius F, Toyoshima C. Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13742-7. doi: 10.1073/pnas.0907054106. Epub 2009 Aug 3. PMID: 19666591; PMCID: PMC2728964.
    O K, Lynn EG, Vazhappilly R, Au-Yeung KK, Zhu DY, Siow YL. Magnesium tanshinoate B (MTB) inhibits low density lipoprotein oxidation. Life Sci. 2001 Jan 12;68(8):903-12. doi: 10.1016/s0024-3205(00)00989-9. PMID: 11213360.
    Parle JV, Franklyn JA, Cross KW, Jones SC, Sheppard MC. Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom. Clin Endocrinol (Oxf). 1991 Jan;34(1):77-83. doi: 10.1111/j.1365-2265.1991.tb01739.x. PMID: 2004476.
    Popovic LM, Mitic NR, Radic I, Miric D, Kisic B, Krdzic B, Djokic T. The effect of exhaustive exercise on oxidative stress generation and antioxidant defense in guinea pigs. Adv Clin Exp Med. 2012 May-Jun;21(3):313-20. PMID: 23214194.
    Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev. 2008 Oct;88(4):1243-76. doi: 10.1152/physrev.00031.2007. PMID: 18923182; PMCID: PMC2909187.
    Razvi S, Shakoor A, Vanderpump M, Weaver JU, Pearce SH. The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis. J Clin Endocrinol Metab. 2008 Aug;93(8):2998-3007. doi: 10.1210/jc.2008-0167. Epub 2008 May 27. PMID: 18505765.
    Reid MB, Stokić DS, Koch SM, Khawli FA, Leis AA. N-acetylcysteine inhibits muscle fatigue in humans. J Clin Invest. 1994 Dec;94(6):2468-74. doi: 10.1172/JCI117615. PMID: 7989604; PMCID: PMC330079.
    Rodondi N, den Elzen WP, Bauer DC, Cappola AR, Razvi S, Walsh JP, Asvold BO, Iervasi G, Imaizumi M, Collet TH, Bremner A, Maisonneuve P, Sgarbi JA, Khaw KT, Vanderpump MP, Newman AB, Cornuz J, Franklyn JA, Westendorp RG, Vittinghoff E, Gussekloo J; Thyroid Studies Collaboration. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010 Sep 22;304(12):1365-74. doi: 10.1001/jama.2010.1361. PMID: 20858880; PMCID: PMC3923470.
    Santi A, Duarte MM, de Menezes CC, Loro VL. Association of lipids with oxidative stress biomarkers in subclinical hypothyroidism. Int J Endocrinol. 2012;2012:856359. doi: 10.1155/2012/856359. Epub 2012 Nov 29. PMID: 23251155; PMCID: PMC3517852.
    Shindoh C, DiMarco A, Thomas A, Manubay P, Supinski G. Effect of N-acetylcysteine on diaphragm fatigue. J Appl Physiol (1985). 1990 May;68(5):2107-13. doi: 10.1152/jappl.1990.68.5.2107. PMID: 2361912.
    Shou Q, Pan Y, Xu X, Xu J, Wang D, Ling Y, Chen M. Salvianolic acid B possesses vasodilation potential through NO and its related signals in rabbit thoracic aortic rings. Eur J Pharmacol. 2012 Dec 15;697(1-3):81-7. doi: 10.1016/j.ejphar.2012.09.044. Epub 2012 Oct 7. PMID: 23051676.
    Sies H, Jones DP. Oxidative stress. In: Fink G, editor. Encyclopaedia of stress. San Diego, CA: Elsevier; 2007. p. 45-48.
    Sieveking DP, Woo KS, Fung KP, Lundman P, Nakhla S, Celermajer DS. Chinese herbs Danshen and Gegen modulate key early atherogenic events in vitro. Int J Cardiol. 2005 Oct 20;105(1):40-5. doi: 10.1016/j.ijcard.2004.10.052. PMID: 16207543.
    Smolders VF, Zodda E, Quax PHA, Carini M, Barberà JA, Thomson TM, Tura-Ceide O, Cascante M. Metabolic Alterations in Cardiopulmonary Vascular Dysfunction. Front Mol Biosci. 2019 Jan 22;5:120. doi: 10.3389/fmolb.2018.00120. PMID: 30723719; PMCID: PMC6349769.
    Tam WY, Chook P, Qiao M, Chan LT, Chan TY, Poon YK, Fung KP, Leung PC, Woo KS. The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients. J Altern Complement Med. 2009 Apr;15(4):415-21. doi: 10.1089/acm.2008.0400. PMID: 19388864.
    Thirumalai, T., Viviyan Therasa, S., Elumalai, E.K., & David, E. Intense and exhaustive exercise induce oxidative stress in skeletal muscle. Asian Pacific Journal of Tropical Disease 2011, 1(1), 63-66.
    Tien AJ, Chien CY, Chen YH, Lin LC, Chien CT. Fruiting Bodies of Antrodia cinnamomea and Its Active Triterpenoid, Antcin K, Ameliorates N-Nitrosodiethylamine-Induced Hepatic Inflammation, Fibrosis and Carcinogenesis in Rats. Am J Chin Med. 2017;45(1):173-198. doi: 10.1142/S0192415X17500124. Epub 2017 Jan 13. PMID: 28081627.
    Tien AJ, Chueh TH, Hsia CP, Chien CT. Monascus Adlay and Monacolin K Attenuates Arterial Thrombosis in Rats through the Inhibition of ICAM-1 and Oxidative Stress. Kidney Blood Press Res. 2016;41(6):815-827. doi: 10.1159/000452584. Epub 2016 Nov 14. PMID: 27838691.
    Tousson, A. J. M. Alghabban, and H. A. Harga, “-yroidectomy induced hepatic toxicity and possible amelioration by Ginkgo biloba leaf extract,” Biomedicine & Preventive Nutrition, vol. 4, no. 6, pp. 391–397, 2014.
    Tseng FY, Lin WY, Lin CC, Lee LT, Li TC, Sung PK, Huang KC. Subclinical hypothyroidism is associated with increased risk for all-cause and cardiovascular mortality in adults. J Am Coll Cardiol. 2012 Aug 21;60(8):730-7. doi: 10.1016/j.jacc.2012.03.047. Epub 2012 Jun 20. PMID: 22726629.
    Tzen JT, Jinn TR, Chen YC, Li FY, Cheng FC, Shi LS, She HKh, Chen BC, Hsieh V, Tu ML. Magnesium lithospermate B possesses inhibitory activity on Na+,K+-ATPase and neuroprotective effects against ischemic stroke. Acta Pharmacol Sin. 2007 May;28(5):609-15. doi: 10.1111/j.1745-7254.2007.00544.x. PMID: 17439716.
    Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39(1):44-84. doi: 10.1016/j.biocel.2006.07.001. Epub 2006 Aug 4. PMID: 16978905.
    Wang CY, Chang TC, Chen MF. Associations between subclinical thyroid disease and metabolic syndrome. Endocr J. 2012;59(10):911-7. doi: 10.1507/endocrj.ej12-0076. Epub 2012 Jul 5. PMID: 22785370.
    Wang LC, Lee TF. Effect of ginseng saponins on exercise performance in non-trained rats. Planta Med. 1998 Mar;64(2):130-3. doi: 10.1055/s-2006-957389. PMID: 9525104.
    Wang SE, Lin CL, Hsu CH, Sheu SJ, Chien CT, Wu CH. Treatment with a herbal formula B401 enhances neuroprotection and angiogenesis in the R6/2 mouse model of Huntington's disease. Drug Des Devel Ther. 2015 Feb 16;9:887-900. doi: 10.2147/DDDT.S78015. PMID: 25733809; PMCID: PMC4338258.
    Wikipedia contributors (2021) Cuneiform. In Wikipedia, The Free Encyclopedia:https://en.wikipedia.org/w/index.php?title=Cuneiform&oldid=1033237931
    Wikipedia contributors (2021) Ebers Papyrus. In Wikipedia, The Free Encyclopedia:https://en.wikipedia.org/w/index.php?title=Ebers_Papyrus&oldid=1033110480
    Wu KC, Chiang BJ, Tsai WH, Chung SD, Chien CT. I-Tiao-Gung extract through its active component daidzin improves cyclophosphamide-induced bladder dysfunction in rat model. Neurourol Urodyn. 2018 Nov;37(8):2560-2570. doi: 10.1002/nau.23815. Epub 2018 Sep 3. PMID: 30252154.
    Wu KC, Lin WY, Sung YT, Wu WY, Cheng YH, Chen TS, Chiang BJ, Chien CT. Glycine tomentella hayata extract and its ingredient daidzin ameliorate cyclophosphamide-induced hemorrhagic cystitis and oxidative stress through the action of antioxidation, anti-fibrosis, and anti-inflammation. Chin J Physiol. 2019 Sep-Oct;62(5):188-195. doi: 10.4103/CJP.CJP_60_19. PMID: 31670282.
    Wu L, Qiao H, Li Y, Li L. Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats. Phytomedicine. 2007 Oct;14(10):652-8. doi: 10.1016/j.phymed.2007.07.060. Epub 2007 Sep 17. PMID: 17870452.
    Wu XJ, Wang YP, Wang W, Sun WK, Xu YM, Xuan LJ. Free radical scavenging and inhibition of lipid peroxidation by magnesium lithospermate B. Acta Pharmacol Sin. 2000 Sep;21(9):855-8. PMID: 11501171.
    Xu YY, Wan RZ, Lin YP, et al. Recent advance on research and application of Salvia miltiorrhiza. Asian J Pharmacodyn Pharmacokinet 2007, 7(2):99-130.
    J. Yao, “General situation of Chinese herbs for hyperthyroidism,” Journal of Chinese Medicine Information, vol. 5, no. 9, pp. 17–19, 1998.
    Yang CC, Chen KH, Hsu SP, CT. Augmented renal prostacyclin by intrarenal bicistronic cyclo-oxygenase-1/prostacyclin synthase gene transfer attenuates renal ischemia-reperfusion injury. Transplantation. 2013;96(12):1043-1051.
    YATVIN MB, WANNEMACHER RW Jr, BANKS WL Jr. EFFECTS OF THIOURACIL AND OF THYROIDECTOMY OF LIVER PROTEIN METABOLISM. Endocrinology. 1964 Jun;74:878-84. doi: 10.1210/endo-74-6-878. PMID: 14190625.
    Yokozawa T, Lee TW, Oura H, Nonaka G, Nishioka I. Effect of magnesium lithospermate B in rats with sodium-induced hypertension and renal failure. Nephron. 1992;60(4):460-5. doi: 10.1159/000186809. PMID: 1584322.
    Zen XX, Yuan Y, Liu Y, Wu TX, Han S. Chinese herbal medicines for hyperthyroidism. Cochrane Database Syst Rev. 2007 Apr 18;2007(2):CD005450. doi: 10.1002/14651858.CD005450.pub2. PMID: 17443591; PMCID: PMC6544778.
    Zhang XD, He CX, Cheng J, Wen J, Li PY, Wang N, Li G, Zeng XR, Cao JM, Yang Y. Sodium Tanshinone II-A Sulfonate (DS-201) Induces Vasorelaxation of Rat Mesenteric Arteries via Inhibition of L-Type Ca2+ Channel. Front Pharmacol. 2018 Feb 2;9:62. doi: 10.3389/fphar.2018.00062. PMID: 29456510; PMCID: PMC5801295.
    Zhou W, Zeng G, Lyu C, Kou F, Zhang S, Wei H. The Effect of Exhaustive Exercise on Plasma Metabolic Profiles of Male and Female Rats. J Sports Sci Med. 2019 Jun 1;18(2):253-263. PMID: 31191095; PMCID: PMC6543993.

    無法下載圖示 本全文未授權公開
    QR CODE