- 期刊
The Microbiota and Chronic Obstructive Pulmonary Diseases
微生物與慢性阻塞性肺疾病
並列摘要
The chronic obstructive pulmonary diseases (COPD) is becoming a more and more serious global lung disease that causes health problems during the recent years. At the year of 2030, COPD is expected to rank as the third highest disease causing human mortality worldwide. Besides smoking, other environmental and host factors may also involve the cause of COPD. Among these, the lung and respiratory tract microbiota are emphasized as close associations to the pathogenesis of COPD. Furthermore, only until recently the lung and respiratory tract microbiota were reported to be a causative effect on COPD induced by lipopolysaccharide (LPS) and elastase caused chronic lung inflammations. By contrast, whether the gut microbiota may involve initiation of COPD pathogenesis remains not characterized. There is necessity that more in-depth and detailed studies have to be performed to clarify the relationship between microbiota and the development of COPD.
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