The rapid developments and changes of information and communication technology (ICT) inspire the great potential for interactive learning. As digital natives, students are situated in various learning scenarios in order to develop 21st Century Competencies. In this paper, we discussed applications, challenges and future research directions of E-schoolbag and classroom of the future. The impact of implementation of information and communication technology has far beyond our imagination. Within this technological impact, we need to have clear goals for the use of technology in the classroom, teaching is the key component for education. The paper provided several recommendations for future research directions regarding the application of instructional strategies, creating engaging learning environments, technology to support collaboration and active learning in order to reach the goal of the innovative learning.