台灣南部健檢成人高尿酸血症與新陳代謝症候群之相關性探討

Association between Hyperuricemia and the Metabolic Syndrome among Adults Attending Health Examination in Southern Taiwan

葉慶輝(Ching-Hui Yeh) ； 吳香錡(Hsiang-Chi Wu)

《中華職業醫學雜誌》 18卷3期 (2011/07) Pp. 197-210

https://doi.org/10.30027/CJOM.201107.0005

摘要

目標：台灣飲食習慣日趨西化，高尿酸血症與代謝症候群病患亦逐年增加，其衍生之相關心血管疾病，勢必對台灣醫療造成更大的負擔，本研究乃針對成人高尿酸血症與代謝症候群之相關性做探討，以提供成人保健政策規劃與後續研究參考。方法：本研究為一橫斷性研究，研究對象為至南部某區域醫院體檢之1150位成人。資料收集主要包括個人基本特性、生活型態、過去病史、檢驗結果等相關因子，並做描述性與卡方統計分析探討，達統計相關變項則進一步執行多變項羅吉斯迴歸分析。結果：在1150位成人中，平均年齡為68.66±13.24歲，高尿酸血症盛行率為37.7%，代謝症候群盛行率為36.6%。卡方檢定結果發現:代謝症候群、個人基本特性（包括性別、年齡、收入、教育程度、停經女性）、生活型態（包括喝酒、運動、喝牛奶習慣、日常交通工具）、過去病史（心血管疾病）及檢驗結果（腰圍、腎功能(BUN、Creatinine)、肝功能(GOT、GPT)、高密度脂蛋白(HDL)、血色素(Hgb)等）與高尿酸血症有關。此外，多變項層級羅吉斯迴歸結果顯示有代謝症候群者、女性、老人、不喜歡喝牛奶、心血管疾病病史、腎功能(BUN、Creatinine)異常、肝功能(GPT)異常、無貧血者，有較大風險會有高尿酸血症。結論：由結果顯示，台灣隨著老年化時代來臨，高尿酸血症與代謝症候群人口也日漸增加，除了定義下之危險因子，也提醒成人應注意日常的生活習慣、飲食與自我保健篩檢，以便維持良好的健康，避免不必要之心血管疾病發生。

關鍵字

健康檢查 ； 高尿酸血症 ； 代謝症候群

並列摘要

Objectives: As the eating habit is changing, the number of patients with hyperuricemia & metabolic syndrome is rising, and the resulting number of cardiovascular diseases will inevitably become an enormous burden for people in Taiwan. The purpose of the current study was to investigate the prevalence and related factors of hyperuricemia & metabolic syndrome in adults, the implications of which could provide impetus for further research and program for health promotion for adults. Methods: The study was a cross-sectional study. Research subjects were comprised of 1150 adults undergoing a health examination in a regional hospital in southern Taiwan. The data collected included socio-demographic variables, lifestyle, history of diseases, and laboratory data. Descriptive and Chi-square tests were used to examine the relationship between hyperuricemia, metabolic syndrome and its related factors. Those statistically significant variables were further selected to establish multiple logistic regression models. Results: Among 1150 adults over 40 yrs of age, the average age was 68.66±13.24 years and the prevalence of hyperuricemia was 37.7% and metabolic syndrome was 36.6%. The results of Chi-square testing revealed that factors, such as socio-demographic variables (including gender, age, income, education level, menopause), lifestyle (including drinking, exercise status, milk intake & daily transportation status), history of diseases (cardiovascular disease), and laboratory data (e.g., abnormal waist circumference、low HDL、GOT or GPT impairment、BUN or Creatinine impairment、normal Hgb) had statistical significance with hyperuricemia. The results of Multiple Hierarchical Logistic Regression showed that metabolic syndrome, female, the elderly, cardiovascular disease Hx, those who do not drink milk, and those with abnormal BUN, Creatinine, GPT & normal Hgb had a relatively high risk of developing hyperuricemia. Conclusions: The results of the current study showed that the prevalence of hyperuricemia & metabolic syndrome are increasing with the aging society in Taiwan. Except being care of the risk factors under the current definition, in order to remain healthy and avoid unnecessary cardiovascular disease, it is necessary for adults to optimize their personal life styles, maintain diet control, and undergo regular health examinations.

並列關鍵字

health examination ； hyperuricemia ； metabolic syndrome